The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

By M. McBurney, Xiaofeng Yang, K. Jardine, M. Hixon, K. Boekelheide, J. Webb, Peter M. Lansdorp, M. Lemieux. Molecular and Cellular Biology, 2003

558 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/87a88991d8c2018d85e0b66685238591276341d6

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Citations in the corpus

• Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ (2012, unknown): “Based on these findings, we probed the browning function of SirT1 in vivo by using three mouse models of altered SirT1 activity: Sirt1 knockout mice (Sirt1 / ) (McBurney et al., 2003); mice”
• SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, background): “Unfortunately, such studies cannot be performed with Sirt1-deficient mice because their postnatal survival rates are very poor and the few surviving mice exhibit many developmental defects (Cheng et al., 2003; McBurney et al., 2003).”
• Mammalian SIRT1 represses forkhead transcription factors. (2004, background): “SIRT1 knockout mice have a severe phenotype, with a high degree of embryonic and postnatal lethality (McBurney et al., 2003; Cheng et al., 2003).”
• Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “Hdac4 knockout mice expose the importance of HDAC4 in skeleton formation, and Sirt1-deficient mice have retinal, bone, and cardiac defects (e.g., McBurney et al. 2003).”
• Sirt1 and the Mitochondria (2016, background): “Sirt1’s knockout phenotype was difficult to interpret, as the mice often died early due largely to developmental defects (Cheng et al., 2003; McBurney et al., 2003).”
• Calorie restriction, SIRT1 and metabolism: understanding longevity (2005, background): “Furthermore, SIRT1 is expressed throughout all mammalian somatic and germ tissues, which makes it a good candidate to regulate the known effects of CR on the soma and the germlin”
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “The main impediment to studying SIRT1 in vivo has been the poor survival, impaired growth, and developmental defects of germline SIRT1 knockout mice (Cheng et al., 2003; McBurney et al., 2003; Sequeira et al., 2008).”
• SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice (2008, unknown): “To probe the transgene’s function, we intercrossed SirBACO with Sirt1 / mice (McBurney et al., 2003).”
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005, background): “Consistent with the previous reports (Langley et al., 2002; McBurney et al., 2003a, 2003b ), SIRT1 is not concentrated in the nucleoli (Figure 1). It is not significantly associated with Hoechst 33342-stained regions, in agreement with the euchromatic localization of mouse Sirt1 (McBurney et al., 2”