Faculty Opinions recommendation of The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

By K. Luebke. 2009

388 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/86e08024f9aae5c84be0198c901e0c0464c2a295

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Citations in the corpus

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. (2011, background): “However, miRNA expression can also be regulated by RBPs at the level of precursor processing (Guil & Cáceres, 2007; Rybak et al., 2008; Trabucchi et al., 2009).”
MicroRNAs in development and disease. (2011, background): “This apparent inconsistency with the reported inhibition of Dicer can be explained by posttranscriptional regulation of miR-29a (291, 426, 618).”
An overview of microRNAs (2015, background): “More recently, other RNA binding proteins have been linked to the regulation of miRNA biogenesis, with activating and repressing roles described[135-138].”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “…to block accumulation of mature let-7 by repression of both Drosha and Dicer activities (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008), recent studies demonstrate that LIN-28 can induce 30 terminal uridylation of pre-let-7 miRNA in mouse embryonic stem (ES)…”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “The miRNA loop also mediates regulatory control over miRNA processing, and KH-type splicing regulatory protein ( KSRP ; also known as FUBP2) has been implicated in this proces”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and KSRP (also known as KHSRP), which are known alternative splicing factors, also serve as auxiliary proteins in the biogenesis of miRNAs, sometimes acting at both the Drosha and Dicer cleavage step”
MicroRNAs in human cancer. (2013, background): “KSRP promotes the biogenesis of a subset of miRNAs, including let-7a, by serving as a component of both DICER1 and RNASEN complexes affecting proliferation, apoptosis and differentiation [103].”