Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

By S. Lebedeva, Marvin Jens, Kathrin Theil, Björn Schwanhäusser, Matthias Selbach, Markus Landthaler, Nikolaus Rajewsky. Molecules and Cells, 2011

689 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1c0680a5688a63d7e851a24c41f4135621e5655

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function (2012, background): “A transcriptomewide analysis revealed that ELAV1-binding sites on mRNA are in close proximity to miRNA-targeting sites, but they do not overlap with each other [99].”
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 (2017, background): “Some lncRNPs can affect gene expression at the transcriptional level; for example, lncRNA ANRIL represses p16INK4 transcription by interacting with the PRC2 complex at the INK4 locus,24 and lncRNA GAS5 binds glucocorticoid receptors (GCRs) and thus acts as a decoy to prevent the transcriptional acti”
Circular RNA and miR-7 in cancer. (2013, background): “About posttranscriptional regulation, inhibition of miR-7-1 biogenesis by HuR and MSI2 was recently shown (26, 27).”
LincRNA-p21 suppresses target mRNA translation. (2012, methodology): “To test these possibilities, we focused on mRNAs encoding b-catenin (CTNNB1) and JunB (JUNB), identified as being translationally repressed after HuR was silenced (López de Silanes et al., 2003; Lebedeva et al., 2011).”
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (2012, background): “Two recent CLIP studies found hundreds of HuR-binding sites that were adjacent to or overlapping with miRNA target sites in unstressed culture cell”
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data (2011, background): “The current investigations of additional amenable photoactivatable nucleosides [38], complemented by the use of different digestion enzymes [24], are expected to reduce potential biases, and can easily be specified in PARalyzer.”
Long Non-coding RNAs in the Cytoplasm (2016, background): “HuR interacts with many coding and non-coding RNAs, indicating its pleiotropic RNA binding activity [92,93].”