Unraveling the role of proteases in cancer.

By J. Koblinski, M. Ahram, Bonnie F. Sloane. Clinica chimica acta; international journal of clinical chemistry, 2000

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Lysosomes in cell death (2004, background): “Role of the lysosomal pathway of cell death in cancer biology Many lysosomal enzymes, including cathepsins, are overexpressed in cancer (Koblinski et al., 2000).”
Extracellular matrix dynamics in development and regenerative medicine (2008, background): “The proteolytic cleavage of ECM components represents another mechanism by which the ECM is remodeled and, when misregulated, results in a number of disease states (Koblinski et al., 2000; Mohamed and Sloane, 2006).”
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis (2005, background): “(MMPs) are not optimally active at the low pHe of the tumour microenvironment, the conversion of the latent MMP pro-form to the active form is dependent on the proteolytic activities of the other protease families, which do have their optimal activity at low pHe (Ref”
Targeting proteases: successes, failures and future prospects (2006, background): “In several processes, it is simpler to talk about protease networks involving multiple classes of proteases that form a system, such as in extracellular matrix degradation in cance”
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. (2004, background): “E and 25 M in F–G. MMPs (reviewed in Koblinski et al., 2000; Rao, 2003).”