Lysosomes in cell death

By M. E. Guicciardi, Marcel Leist, G. Gores. Oncogene, 2004

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Cathepsin D--many functions of one aspartic protease. (2008, background): “Partial lysosomal permeabilization, with subsequent release of proteolytic enzymes into cytosol, and their active contribution to the apoptosis signaling pathways, has been described in several models of apoptosis [83].”
Lysosomal membrane permeabilization in cell death (2008, background): “Under these circumstances, proteases liberated from the lysosomal lumen activate a controlled mode of cell death (for earlier reviews see Guicciardi et al., 2004; Kroemer and Jaattela, 2005; Tardy et al., 2006; Terman et al., 2006).”
Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “This sequence of events is supported by recent observations that a high degree of lysosomal membrane destabilization early after nanoparticle exposure may lead to excessive leakage of lysosomal contents into the cytoplasm causing cell death [97-99].”