Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila.

By P. Plaçais, Severine Trannoy, Anja B. Friedrich, Hiromu Tanimoto, T. Préat. 2013

119 citations recorded by the source corpus.

One of the challenges facing memory research is to combine network- and cellular-level descriptions of memory encoding. In this context, Drosophila offers the opportunity to decipher, down to single-cell resolution, memory-relevant circuits in connection with the mushroom bodies (MBs), prominent structures for olfactory learning and memory. Although the MB-afferent circuits involved in appetitive learning were recently described, the circuits underlying appetitive memory retrieval remain unknown. We identified two pairs of cholinergic neurons efferent from the MB α vertical lobes, named MB-V3, that are necessary for the retrieval of appetitive long-term memory (LTM). Furthermore, LTM retrieval was correlated to an enhanced response to the rewarded odor in these neurons. Strikingly, though, silencing the MB-V3 neurons did not affect short-term memory (STM) retrieval. This finding supports a scheme of parallel appetitive STM and LTM processing.

Subfields: Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics, Immunology

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “For example, even though several cholinergic MBONs are required for appetitive memory (Placais et al., 2013), the compartments with cholinergic MBONs do not receive inputs from reward-mediating PAM cluster DANs, but instead from PPL1 cluster DANs that have been shown to be dispensable for…”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “Genetic manipulation has also implicated specific subsets of MBONs in the mediation of learned appetitive and aversive behaviors (Sejourne et al., 2011; Pai et al., 2013; Placais et al., 2013; Aso et al., 2014).”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, background): “Physiological changes after training have been reported in two sets of memory-relevant cholinergic output neurons that have dendritic fields within the vertical lobes of the mushroom body (Séjourné et al., 2011; Pai et al., 2013; Plaçais et al., 2013).”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “Another type of MBONs also mediates appetitive LTM retrieval: MBON-α3 (also known as MB-V3) (Placais et al., 2013).”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…neuron is GABAergic (previously shown by (Chen et al., 2012)), both the MBON- 5 2a and MBON- 2 2a neurons are glutamatergic (consistent with the findings of (Aso et al., 2014b)), and the MBON 3 and V2 neurons are cholinergic (previously shown by (Placais et al., 2013) and (Sejourne et al., 2011)).”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “The role for α3 MBONs has been disputed (Pai et al., 2013; Plaçais et al., 2013).”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in others (Bouzaiane et al., 2015; Owald et al., 2015; Pai et al., 2013; Plaçais et al., 2013).”