Mitochondrial threshold effects.

By R. Rossignol, B. Faustin, Christophe Rocher, M. Malgat, J. Mazat, T. Letellier. Biochemical Journal, 2003

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations (2010, positive): “Such diseases typically show a ‘‘threshold effect,’’ in that clinical signs manifest only when the level of pathogenic mtDNA in a particular cell lineage breaches a critical level (DiMauro and Schon, 2003; Rossignol et al., 2003).”
The Mitochondrial Basis of Aging (2016, background): “…of copies per cell, the detection of mutant mtDNA does not, in itself, imply dysfunction, as it is generally believed that mutational load must exceed a threshold value (perhaps exceeding 60%of all mitochondria within a given tissue) for there to be a significant phenotype (Rossignol et al., 2003).”