Activation and signaling of the p38 MAP kinase pathway

By Tyler Zarubin, Jiahuai Han. Cell Research, 2005

1,623 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8667cdf7e3578a42f00b0294406b664d7a1363de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Karin
2. Walter Kolch
3. J. Campisi
4. E. Kurutaş

In Molecular Biology

1. J. Campisi
2. Adam Freund
3. C. Patil
4. M. Karin
5. T. Lawrence
6. R. Seger
7. S. Hagan
8. Walter Kolch

Citations in the corpus

• Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. (2007, background): “MAP kinase-activated protein kinase 2, is a downstream target of p38 MAPK (Zarubin and Han, 2005) and c-jun is a downstream target for JNK (Holzberg et al, 2003).”
• MAP kinase signalling pathways in cancer (2007, background): “…pathway In mammals, p38 isoforms are strongly activated by environmental stresses and inflammatory cytokines. p38 is required for expression of TNFa and interleukin-1 during inflammatory responses and most stimuli that activate p38 also induce expression of the p38 protein (Zarubin and Han, 2005).”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “…upon receptor engagement, activate several effector pathways, the most important of which include mitogen-activated protein kinases (MAPK), especially JNK (Karin and Gallagher, 2005) and p38 MAPK (Zarubin and Han, 2005), as well as IkB kinases (IKK) and their relatives (Ghosh and Karin, 2002).”
• The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “…on similar, as well as distinct targets lead to integration of the MAPK and other signals, and allow progression of nuclear processes such as transcription [44], chromatin remodeling [149], protein stability [150], subcellular localization [81], and even cell cycle progression [151].”
• The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “The activity of MAP kinases (ERK, c-Jun and p38) is regulated by phosphorylation cascades: MAPKs activation is induced through the phosphorylation of their threonyl and tyrosyl residues within a tripeptide motif TXY by a dual specificity kinase termed MAP kinase kinase (MKK), which in turn is phosph”
• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes (2012, background): “For western blotting of p38 MAPK (total and phosphorylated), training was performed as described in stimulation experiments.”
• p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype (2011, background): “…NF-jB activity in senescent cells Because p38MAPK is known to regulate the activity of multiple transcription factors (TFs) depending on context (Zarubin and Han, 2005), we examined the promoters of p38MAPKinduced factors (Figure 3D) for overrepresented transcription factor-binding sites (TFBS).”
• Human Coronavirus: Host-Pathogen Interaction. (2019, background): “The activation of p38, ERK, and JNK pathways during HCoV infection is discussed below (Figure 7). p38 Pathway Activated p38 translocates to the nucleus and directly or indirectly phosphorylates a broad range of substrate proteins, including important transcription factors such as cAMP response eleme”