Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.

By Yi Xu, C. Jagannath, Xian-de Liu, A. Sharafkhaneh, K. Kołodziejska, N. Eissa. Immunity, 2007

896 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/0c8e9f1b19ce9621f9ca1ed288ff26efbc2631f6

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In Epidemiology

1. V. Deretic
2. D. Tang
3. R. Kang
4. Beth Levine
5. Michael Lotze
6. H. J. Zeh
7. Carolyn B. Coyne
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In Immunology

1. L. Franchi
2. H. J. Zeh
3. D. Tang
4. R. Kang
5. N. Warner
6. G. Núñez
7. Kyle L. Viani
8. T. Wyss‐Coray

Citations in the corpus

• Autophagy, Immunity, and Microbial Adaptations (2009, background): “…The innate immunity functions identified to date encompass both effector outputs (Delgado et al., 2008; Sanjuan et al., 2007; Shelly et al., 2009; Xu et al., 2007) and regulatory roles, some of which are in conjunction with PRRs (Jounai et al., 2007; Lee et al., 2007; Saitoh et al., 2008; Tal et…”
• Activation of Autophagy by Inflammatory Signals Limits IL-1β Production by Targeting Ubiquitinated Inflammasomes for Destruction (2012, neutral): “In macrophages, autophagy can be triggered by the engagement of Toll-like receptor”
• NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation (2010, background): “Recently, it has been shown that signaling through TLRs can lead to autophagosome formatio”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “In contrast, TLR4 is required for PAMPs such as LPS to induce autophagy in macrophages (108), suggesting that the induction of autophagy by DAMPs or PAMPs may have alternative receptordependent pathways.”
• Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality (2011, neutral): “receptors, including Toll-like receptors (TLR) and nucleotidebinding and oligomerization domain (NOD)-like receptors (NLR), induce autophagy in macrophages.(74,75) Mitroulis et al.”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Microbial ligands are known activators of signaling pathways that increase autophagy (223, 224).”
• Toll‐like receptors control autophagy (2008, background): “A stereometric quantification of organellar surface density in a volume (Sv) (Weibel and Bolender, 1973) showed that, upon stimulation with ssRNA, only autophagic vacuoles increased their Sv value from &2008 European Molecular Biology Organization The EMBO Journal VOL 27 | NO 7 | 2008…”
• The known unknowns of antigen processing and presentation (2008, background): “In addition to cytokines, TLR ligands, including LPS and the TLR7 ligands imiquimod and single-stranded RNA, can induce autophagy in macrophages and enhance mycobacterial co-localization with autophagosomes, therefore resulting in the elimination of this pathoge”
• Unveiling the roles of autophagy in innate and adaptive immunity (2007, background): “found that the Gram-negative bacterial lipopolysaccharide induces autophagy in macrophages through a TLR4 signalling pathwa”