Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs1

By J. Olson, S. Miller. Journal of Immunology, 2004

1,256 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/85cdd6d336f17a4203d1112b0d8bcce92fd57c38

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Citations in the corpus

The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “Murine microglia have been shown to express the mRNA for all TLRs (TLR 1–9) (Olson and Miller, 2004) and can be strongly activated after in vitro stimulation with their specific agonists, especially LPS, which includes mounting a strong inflammatory cytokine response (Ebert et al., 2005).”
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens (2006, background): “; that microglia in the CNS express TLRs after exposure to various pathogens or pathogen products, such as LPS, peptidoglycans and CpG DNA; and that mice deficient in the TLR adaptor protein MyD88 (myeloid differentiation primary-response gene 88) show a decreased CNS-mediated inflammatory respons”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Their Tolllike receptor (TLR) complement comprises at minimum TLR1 through TLR9, but relative expression levels and signaling efficiency have not been defined (55).”
Genomic Analysis of Reactive Astrogliosis (2012, background): “Whereas LPS activates TLR4 receptors on microglia and macrophages (Buttini and Boddeke, 1995; Poltorak et al., 1998; Olson and Miller, 2004), which in turn secrete signals that induce reactive astrogliosis, MCAO exposes all brain cells within its territory to ischemia and causes direct cell death an”
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia (2008, background): “MHC II [45], but one key difference from our study is that the induction of EAE pathology requires functional antigen presentation on MHC II [60].”
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “Other microglial Aβ related receptors Microglia may express other putative Aβ receptors, including Toll-like receptor 2/4 (TLR2/4) [362], complement receptor 3 (CR3) [363], Fc γ receptors IIb (FcγRIIb) [364], CD36 [365, 366], advanced glycation end product receptor (RAGE) [367].”
TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes1 (2005, background): “Both cell types show functional responses to TLR ligation (19, 21).”
Microglia: active sensor and versatile effector cells in the normal and pathologic brain (2007, background): “For example, the families of pattern recognition receptors, such as Toll-like receptors (TLRs), detect and differentiate viral, bacterial and fungal structures [ 10 ,11].”