A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

By Mitsuko Hayashi-Nishino, Naonobu Fujita, Takeshi Noda, A. Yamaguchi, T. Yoshimori, A. Yamamoto. Nature Cell Biology, 2009

1,066 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/85ace2a45846241f56abc02f85c97c64f7bca852

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Citations in the corpus

LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis (2010, background): “In agreement with our model, removal of both subfamilies by Atg4B led to the accumulation of small autophagic membranes (Fujita et al, 2008a; Hayashi-Nishino et al, 2009).”
mTOR regulation of autophagy (2010, background): “partment that seems to be derived from ER membranes in response to amino acid starvation [81,82].”
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation (2014, background): “Previous studies have shown that early autophagic machinery, including the omegasome marker DFCP1 (22, 34), is recruited independently and before LC3 during mitophagy (35).”
Mitochondria supply membranes for autophagosome biogenesis during starvation (2010, background): “Electron microscopy (EM) tomography has revealed close apposition of ER and phagophore membranes, most apparent when phagophore maturation is blocked (Hayashi-Nishino et al., 2009; Ylä-Anttila et al., 2009).”
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “Although an equivalent structure seems to be absent from mammalian cells, a special subdomain in the endoplasmic reticulum (ER) termed the “omegasome” has been suggested as a putative origin of autophagosomes (3, 33, 115).”
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons (2012, background): “Possible sources include endocytosed plasma membrane, ER, mitochondria, or Golgi membranes (Hollenbeck, 1993; Hayashi-Nishino et al., 2009; Hailey et al., 2010; Ravikumar et al., 2010; van der Vaart and Reggiori, 2010; Yen et al., 2010).”
Autophagy in immunity and inflammation (2011, background): “The ER cisternae often associate with developing autophagosomes, and electron tomography analysis has demonstrated direct connections between the ER and autophagosomal membranes 10, 11 .”
Autophagy and the integrated stress response (2010, positive): “During autophagy, cells form double-membraned vesicles, autophagosomes, that sequester organelles, proteins, or portions of the cytoplasm for delivery to the lysosome (He and Klionsky, 2009).”
Autophagy: assays and artifacts (2010, background): “TEM has recently been used to great effect in combination with tomographical approaches to identify regions of the endoplasmic reticulum as the likely origin of autophagosomes in mammalian cells [6,7].”