Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

By J. Imitola, K. Raddassi, K. Park, Franz‐Josef Mueller, M. Nieto, Y. Teng, D. Frenkel, Jianxue Li, R. Sidman, C. Walsh and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,133 citations recorded by the source corpus.

Subfields: Ecology, Ecology, Evolution, Behavior and Systematics, Plant Science

View Paper: https://www.semanticscholar.org/paper/8591f5447f4423c60ccf55e5089cdfc1934559b8

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Citations in the corpus

Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “Upregulation of SDF-1 immunoreactivity was detected at all time points in reactive astrocytes in the penumbra area [30, 32 ].”
Astrocytes, from brain glue to communication elements: the revolution continues (2005, background): “, and might drive reparative neural stem cells to lesion site”
Substrate modulus directs neural stem cell behavior. (2008, background): “Furthermore, local variation in stiffness could be used as a control parameter to tune cell differentiation in the brain, and stiffness could play a role in central nervous system pathology, including injury homing responses of NSCs to stiff glial scars or areas of hypoxia (49).”
A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “…niche Ang1 and SDF1 are expressed by endothelial cells, upregulated by hypoxia after stroke, and directly regulate stem cell differentiation or migration through their receptors Tie2 and CXCR4 (Jones et al., 2001; Stumm et al., 2002; Arai et al., 2004; Imitola et al., 2004; Robin et al., 2006).”
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells (2008, background): “). The ependyma-derived cells migrating to the lesion appeared less numerous after a lateral than after a dorsal incision, suggesting that severance of ependymal cell processes in the midline is not necessary for the activation of ependymal cells, but that it may augment their reaction. The migratio”
The therapeutic potential of neural stem cells (2006, neutral): “and chemokine receptors (such as CCR1 , CCR2, CCR5, CXCR3 and CXCR4”