Substrate modulus directs neural stem cell behavior.

By Krishanu Saha, Albert J. Keung, E. Irwin, Yang Li, Lauren E. Little, David V. Schaffer, K. Healy. Biophysical Journal, 2008

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Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “The stickiness of these polymers can be chemically tuned and used to reproduce the stiffness of healthy and pathological tissue and thus control differentiation and selfrenewal of stem cells [77,78,80,81,90].”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, background): “of this effect is somewhat surprising, ECM rigidity has been observed to modulate cell growth in other systems, including fibroblasts (44), hepatocytes (45), and neural stem cells (46).”
Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “Even stem cell populations not traditionally regarded as “load-bearing” are sensitive to these mechanical cues; for example, when adult neural stem cells are presented with ECMs of various mechanical rigidities and cultured in mixed differentiation media, soft matrices promote neuronal cultures and ”
The Influence of Hydrogel Modulus on the Proliferation and Differentiation of Encapsulated Neural Stem Cells (2009, positive): “have also studied the influence of the mechanical properties of the substrate on the behavior of neural stem cells (NSCs) [15].”
The biophysics of neuronal growth (2010, methodology): “Interestingly, even neural stem cell fate can be directed using mechanical cues [175, 188–193].”