Astrocytes, from brain glue to communication elements: the revolution continues

By Andrea Volterra, J. Meldolesi. Nature Reviews Neuroscience, 2005

1,759 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/61822f8f54104dc6a40212c6e796f277b75568d3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Maiken Nedergaard
2. Igor Allaman
3. Pierre J. Magistretti
4. Philip Haydon
5. Andrew H. Miller
6. Andrea Volterra
7. Charles L Raison
8. Giorgio Carmignoto

In Developmental Neuroscience

1. Maiken Nedergaard
2. Andrew H. Miller
3. Charles L Raison
4. Pierre J. Magistretti
5. Igor Allaman
6. E. Haroon
7. C. Nicholson
8. E. Sykova

In Neurology

1. Maiken Nedergaard
2. Andrew H. Miller
3. Charles L Raison
4. Philip Haydon
5. Igor Allaman
6. Pierre J. Magistretti
7. C. Iadecola
8. E. Haroon

Citations in the corpus

• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “Cytokines have been shown to have profound effects on glutamate metabolism, including a rich literature demonstrating that cytokines can (1) decrease the expression of glutamate transporters on relevant glial elements and (2) increase the release of glutamate from astrocytes (Bezzi et al, 2001; Pitt”
• Energy Metabolism in Astrocytes: High Rate of Oxidative Metabolism and Spatiotemporal Dependence on Glycolysis/Glycogenolysis (2007, background): “Their biosynthetic and oxidative capabilities are essential for glutamate and GABA synthesis and glutamate– glutamine cycling, and disruption of these processes quickly alters neuronal function.”
• Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “A related pathway to pathology in inflammation-induced effects on behavior includes the capacity of cytokines and inflammatory mediators to increase glutamate release and decrease the expression of glutamate transporters on relevant glial elements, thereby decreasing glutamate reuptake (68,71,75,79,”
• Spatio-Temporal Credit Assignment in Neuronal Population Learning (2011, neutral): “Some recent research has further highlighted astrocytes as local communication elements which are capable of modulating synaptic plasticity [30,31].”
• Glutamate exocytosis from astrocytes controls synaptic strength (2007, methodology): “and the ultrastructural identification of synaptic-like microvesicles (SLMVs) equipped with the machinery for storing and releasing glutamate in astrocytes of the adult hippocampu”
• Uniquely hominid features of adult human astrocytes (2009, background): “Adult astrocytes in the rodent brain respond to both ATP and glutamate (Volterra and Meldolesi, 2005).”
• Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “We do not attempt to discuss the roles of chemokines released from these glial cells, and instead alert the reader to an excellent recent review on this topic (219).”
• The synapsins: key actors of synapse function and plasticity. (2010, background): “…to highlight at this point that both astrocytes and b cells show many similarities to neurons, in that, for example, they secrete classical and peptide transmitters by regulated exocytosis, and express a range of transmitter-synthesising enzymes (Reetz et al., 1991; Volterra and Meldolesi, 2005).”
• Astrocyte dysfunction in neurological disorders: a molecular perspective (2006, background): “Neuronal stimulation can increase astroglial [Ca 2+ ] i through activation of ionotropic and/or metabotropic glutamate receptors (iGluRs and mGluRs, respectively), GABA B (γ-aminobutyric acid type B) receptors or acetylcholine receptors, which implies the existence of manifold bidirectional comm”
• The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus (2006, background): “Intriguingly, astrocytes have been recognized to actively modulate neuronal communication (Volterra and Meldolesi, 2005), in addition to their more established functions in regulating the extracellular milieu.”
• Astrocytes are endogenous regulators of basal transmission at central synapses. (2011, neutral): “, purines, D-serine, and glutamate) (Halassa and Haydon, 2010; Volterra and Meldolesi, 2005).”
• The blood-brain barrier: an engineering perspective (2013, background): “…concentration, the clearance of neurotransmitters, proliferation of stem cells, control of the number of synapses, and maintenance of the BBB (Ullian et al., 2001; Lee et al., 2003; Volterra and Meldolesi, 2005; Abbott et al., 2006; Fiacco et al., 2009; Freeman, 2010; Halassa and Haydon, 2010).”
• Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…and associated inflammatory mediators have been shown to stimulate the release of glutamate from glial elements and decrease glutamate reuptake, in part through downregulation of glutamate transporters(Pitt et al., 2003; Volterra and Meldolesi, 2005; Tilleux and Hermans, 2007; Ida et al., 2008).”
• Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function (2009, background): “This emphasizes the concept of tripartite synapses in the brain, whereby synaptic activity is tuned by astrocyte-derived regulatory signals (480).”