A Critical Role for IL-21 in Regulating Immunoglobulin Production

By K. Ozaki, R. Spolski, C. Feng, Chen-feng Qi, Jun Cheng, A. Sher, H. Morse, Chengyu Liu, P. Schwartzberg, W. Leonard. Science, 2002

1,063 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/8577015119e8b087fb2812718e09099d80748f40

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In Immunology

Citations in the corpus

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “Thus, Tfh cells turn down IFN-g but do produce IL-21, which serves as a potent B cell stimulator, and favors switching to IgG1while repressing IgE (Ozaki et al., 2002).”
New insights into the regulation of T cells by γc family cytokines (2009, neutral): “Although Il21r −/− mice have normal numbers of peripheral CD8 + T cell”
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “Analysis of basal serum Igs revealed the reported reduction in serum IgG1 and elevated IgE titers in the absence of IL-21 (Fig. 1, A and B; Ozaki et al., 2002).”
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism (2010, background): “This paper confirms a requirement for IL-21 in the efficient formation of early ASC (Ozaki et al., 2002; Ettinger et al., 2008; Odegard et al., 2008) and extends these results to show an important role for this cytokine in the persistence of GC.”
Follicular B helper T cells in antibody responses and autoimmunity (2005, background): “This is consistent with a reduction in serum IgG1 concentrations in IL-21R-deficient mic”
Dissolving Polymer Microneedle Patches for Influenza Vaccination (2010, background): “, as well as regulating B cell isotype class switchin”
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, background): “However, some studies have found limited effects of IL-4 deficiency on the GC response, suggesting differential contributions of IL-4 depending on the type of response, perhaps reflecting redundancy in some cases with IL-21, a related cytokine expressed by follicular Th cells (50, 51).”
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, background): “Tfh cells produce a variety of cytokines, including IL-21 which is critical for promoting B cell maturation (Ozaki et al., 2002; Chtanova et al., 2004; Fazilleau et al., 2009a,b; Avery et al., 2010).”
IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “In XSCID and JAK3-deficient SCID, the lack of signaling by IL-7 and IL-15, respectively, explains the lack of T and NK cell development [5], whereas defective signaling by IL-4 and IL-21 together explain the non-functional B cells and hypogammaglobulinemia found in this disease [9].”