PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles.

By Swaroop Mishra, P. Webster, Mark E. Davis. European Journal of Cell Biology, 2004

706 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/855244f265af674f81ccbfd5898c81b791cb3d68

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In Genetics

1. Allan S. Hoffman
2. M. Kay

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Citations in the corpus

• A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. (2011, background): “Furthermore, PEGylation improves the stability of nanoparticles, which results in poor endosomal escape via membrane fusion and in well degradation of cargos in lysosomes, digestive compartments [15,16].”
• Current status of polymeric gene delivery systems. (2006, background): “Direct PEGylation of PEI/ DNA complexes with a methoxy-PEG-succimidyl propionate (5 kDa) also reduced the extent of interparticular aggregation of the complexes [49].”
• Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy (2012, background): “In addition to preventing interactions between nanoparticles and opsonins, PEGylated surfaces can also reduce interactions between nanoparticles and cell surfaces [23-26].”
• Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery (2017, background): “After PEGylation, nanocarriers cannot be effectively receptor-mediated endocytosis in cancer cells of carcinoma tissue (Song et al., 2002; Mishra et al., 2004; Magarkar et al., 2012).”
• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “PEGylation has been shown to sterically interfere with membrane fusion of lipid-based NPs, resulting in the poor endosome escape [90, 196].”
• Design and development of polymers for gene delivery (2005, background): “PEGylation, however, has been shown to reduce internalization of untargeted polyplexes and to alter intracellular traffickin”