Current status of polymeric gene delivery systems.

By T. Park, J. Jeong, S. W. Kim. Advanced Drug Delivery Reviews, 2006

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Nonviral Gene Delivery: Principle, Limitations, and Recent Progress (2009, neutral): “Among these are aminoesters or oligoamines polymerized through disulfide linkages or polyamino acid derivatives with proton absorption capacities (91).”
On the nature of biomaterials. (2009, background): “It is well-known, of course, that these so-called non-viral vectors have been introduced because of concerns over the viral vectors, for which safety issues still exist, even though they are far more efficient than the non-viral vectors at this stage [46].”
State-of-the-art gene-based therapies: the road ahead (2011, methodology): “To create delivery platforms, DNA has been complexed to many different types of macromolecules, including those based on polylysine, polyethylenimine, polysaccharides (for example, cyclodextrin and chitosan) and/or other polycationic-lipid-based system”
siRNA vs. shRNA: similarities and differences. (2009, background): “viral nucleic delivery is that transfection efficiency usually correlates with toxicity [161,162].”