A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.

By H. Hatakeyama, H. Akita, H. Harashima. Advanced Drug Delivery Reviews, 2011

634 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a8fd0acc867d5232655b3197939e2ab9b46a43c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. N. Bertrand
2. Xiaoyang Xu
3. O. Farokhzad
4. Xueqing Zhang

In Molecular Biology

1. N. Bertrand
2. Xiaoyang Xu
3. J. Hanes
4. O. Farokhzad
5. L. Ensign
6. Xueqing Zhang
7. Namho Kim
8. J. S. Suk

Citations in the corpus

• Cancer Nanomedicine: From Targeted Delivery to Combination Therapy (2015, background): “surface charge of these particles allows more efficient cellular uptake than the highly hydrophilic PEG NP [26,27,31].”
• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “PEGylation has been shown to sterically interfere with membrane fusion of lipid-based NPs, resulting in the poor endosome escape [90, 196].”