Design and development of polymers for gene delivery

By D. W. Pack, Allan S. Hoffman, S. Pun, P. Stayton. Nature reviews. Drug discovery, 2005

2,416 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aa020c55c45746926834fda58e94d5dc513ea616

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In Genetics

Nicholas A. Peppas

In Molecular Biology

Citations in the corpus

Polymers for Drug Delivery Systems (2010, background): “The high osmotic strength within the endosomal compartment subsequently leads to osmotic swelling and endosomal rupture (130).”
Chitosan-based formulations for delivery of DNA and siRNA. (2010, background): “Several factors affect the targeting efficiency, including the degree of ligand substitution, conjugation chemistry, spacer length between the ligand and polymer, and binding strength between the ligand and receptor [102].”
Polymer conjugates as anticancer nanomedicines (2006, background): “and multi-component polyplexes (containing covalent linkers) being developed as non-viral vectors for gene and protein deliver”
Cell-penetrating peptides: design, synthesis, and applications. (2014, background): “Another, the proton sponge theory, proposes that endosomes burst due to osmotic pressure.(69) If the complexes remain trapped inside the endosomes, they can be subjected to lysosomal degradation which abolishes the biological effect of the cargo.”
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues (2008, background): “The dual capacity to form polyvalent adhesive interactions via both hydrophobic and anionic forces represents a particularly challenging problem for polymeric nanoparticles designed to deliver drugs and genes, since many commonly used biomaterials are either hydrophobic, such as poly(lactideco-glyco”
Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery. (2008, background): “The most important feature of the CD-containing cationic polymer gene delivery system is that the polyplexes formed between the polymers and DNA can be further modified by inclusion complex formation since there are a lot of CD moieties [112,117].”
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018, background): “Besides, in contrast with viral vectors, cumulative editing efficacy can be obtained after multiple administrations of non-viral vectors-mediated CRISPR/Cas9 delivery owing to limited immune responses [73, 74, 116, 138].”