Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

By M. Yu, Jinho Park, S. Jon. Theranostics, 2012

824 citations recorded by the source corpus.

Nanomaterials offer new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions including targeting, imaging, therapy, and etc have been intensively studied aiming to overcome limitations associated with conventional cancer diagnosis and therapy. Of various nanoparticles, magnetic iron oxide nanoparticles with superparamagnetic property have shown potential as multifunctional nanoparticles for clinical translation because they have been used asmagnetic resonance imaging (MRI) constrast agents in clinic and their features could be easily tailored by including targeting moieties, fluorescence dyes, or therapeutic agents. This review summarizes targeting strategies for construction of multifunctional nanoparticles including magnetic nanoparticles-based theranostic systems, and the various surface engineering strategies of nanoparticles for in vivo applications.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/c0c8145b79411835ad50e45b6e6808dc78ffb026

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. N. Bertrand
2. N. Kamaly
3. Xiaoyang Xu
4. Jun Wu
5. O. Farokhzad
6. K. El-Say
7. Hossam S. El-Sawy
8. S. E. Achy

In Biomedical Engineering

1. N. Bertrand
2. Xiaoyang Xu
3. N. Kamaly
4. Jun Wu
5. K. El-Say
6. Hossam S. El-Sawy
7. O. Farokhzad
8. S. E. Achy

Citations in the corpus

• Sol-gel based materials for biomedical applications (2016, background): “Surface modifications may be easily introduced through conjugation with targeting moieties, fluorescence dyes, genes, or drugs to provide multimodal functionalities [21,545].”
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “For example, some proteins lose their functions in organic solvents and they are too large to participate in the NP polymer selfassembly process [180].”
• Polymeric nanoparticles: Promising platform for drug delivery. (2017, background): “Current developments in nanotechnology have revealed many types of targeting strategies for augmenting drug accumulation into the tumour while restricting the undesirable toxicity to normal cells, as the PNPs designed for targeted drug delivery systems (TDDS) can increase the tissue specific antican”
• Cancer active targeting by nanoparticles: a comprehensive review of literature (2014, background): “As targeting agents, antibodies have exceedingly high selectivity and binding affinity by virtue of the presence of two epitope binding sites in a single molecule (Yu et al. 2012).”
• Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, neutral): “[106 ,107] Long circulation of carriers would prevent active targeting and cellular uptake.”
• Therapeutic Nanoparticles and Their Targeted Delivery Applications (2020, background): “However, in active targeting, the surface of the nanoparticle is coupled with at least one kind of targeting moiety such as, proteins, peptides, nucleic acids, antibodies, or small molecules [12].”