Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.

By M. A. Sutton, Hiroshi T. Ito, Paola A Cressy, Christian Kempf, Jessica C. Woo, E. Schuman. Cell, 2006

624 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8409308b9659942c30a29490759b68f6a4a2bd4b

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity (2008, background): “Interestingly, blocking neuronal activity with TTX alone for 24 hr, a protocol that induces a mechanistically distinct form of synaptic scaling (Sutton et al., 2006), did not yield a significant increase in the GFP reporter expression (Figures 3C and 3D).”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (neutral): “…some studies suggest that it is also possible for scaling-like processes to occur at a more local level, perhaps even at individual synapses (Sutton et al., 2006; Branco et al., 2008; Frontiers in Synaptic Neuroscience www.frontiersin.org June 2010 | Volume 2 | Article 5 | 4 from glial…”
Dendritic excitability and synaptic plasticity. (2008, positive): “However, recent studies suggest a slow time course may not be necessary but that apparently homeostatic mechanisms are sometimes rapidly induced (222, 631, 750, 798, 799).”
Dendritic protein synthesis, synaptic plasticity, and memory. (2006, background): “Spatially restricted perfusion of protein-synthesis inhibitors implicates dendritic translation in synaptic plasticity (e.g., Bradshaw et al., 2003; Sutton et al., 2006).”
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses (2008, background): “In contrast, synaptic scaling is robustly observed after 4–24 hr of activity blockade in the majority of studies and is a graded process that produces measurable changes in synaptic accumulation of AMPA receptors within a few hours, and synaptic strength continues to increase as the duration of acti”
Rapid synaptic scaling induced by changes in postsynaptic firing. (2008, background): “It also remains unclear which aspect of activity is sensed by neurons or networks during synaptic scaling: it has variously been proposed that neurons sense their own firing rate and globally scale synaptic weights up or down to compensate (Turrigiano and Nelson, 2004); that local changes in synapti”
Spatially restricting gene expression by local translation at synapses (2010, neutral): “Following chronic silencing of activity, eEF2-becomes dephosphorylated (active) and local protein synthesis is triggered, which is required to rapidly increase synaptic expression of GluR1 and maintain synaptic homeostasis in the circuit [56].”
Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “Moreover, neuronal activity can also regulate the local dendritic synthesis of AMPARs and their abundance at synapse”
Dendritic mRNA: transport, translation and function (2007, positive): “Although most studies of dendritic protein synthesis have focused on regulation by evoked neuronal activity, others have shown that dendritic protein synthesis in dissociated hippocampal neurons is tonically suppressed by spontaneous, action-potential-independent neurotransmitter releas”
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. (2012, background): “Interestingly, when global block of firing with TTX is combined with local glutamate receptor block, there is a local enhancement of GluA1 accumulation at the blocked synapses (Sutton et al. 2006).”