Rapid synaptic scaling induced by changes in postsynaptic firing.

By K. Ibata, Qian-Quan Sun, Gina G. Turrigiano. 2008

464 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Electrical and Electronic Engineering

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Electrical and Electronic Engineering

Citations in the corpus

The temporal paradox of Hebbian learning and homeostatic plasticity (2017, background): “Homeostatic plasticity, on the other hand, acts on much longer timescales of hours to days [14, 16, 19, 29, 55, 56, 80].”
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses (2008, methodology): “This pool of active kinase is reduced by brief treatment with tetrodotoxin, whereas transfection with a dominant negative form of CaMKIV (or pharmacological inhibition of CaMKK) increases mEPSC amplitude and occludes the effects of tetrodotoxin (Ibata et al., 2008).”
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. (2012, background): “2), and both involve changes in signaling through the CaMKK/CaMKIV pathways (Ibata et al. 2008; Goold and Nicoll 2010), several other signaling and trafficking elements known to be important or essential for scaling up are dispensable for scaling down, including BDNF, TNFa, Arc, and PICK1 (Rutherfor”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (unknown): “Furthermore, these changes happened only once synapses had been already established, and in fact opposite effects were observed when activity levels were reduced in younger cultures, when synapses were BaSIc experImental evIdence Synaptic scaling generally occurs on a much slower timescale than Hebb”
Spontaneous network activity and synaptic development (2013, unknown): “Email: dkerschensteiner@wustl.edu”
Synaptic Plasticity in Neural Networks Needs Homeostasis with a Fast Rate Detector (2013, background): “Although it is generally associated with long timescales (order of days), also more rapid forms of scaling are known [54– 56] of which some indeed act on the order of minutes [57].”