TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

By Liang Zhou, Jared E. Lopes, M. Chong, I. Ivanov, Roy Min, Gabriel D. Victora, Yuelei Shen, Jianguang Du, Y. Rubtsov, Alexander Y. Rudensky and 2 more. Nature, 2008

1,645 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/83c54cd042b833bc203bf16c92c98a70945dc67d

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In Immunology

Citations in the corpus

Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Yet several lines of evidence indicate that plasticity is particularly pronounced between Th17 cells and iTregs (Lee et al., 2009), and an intermediate state with expression of both RORγt and Foxp3 at the same time was observed (Lochner et al., 2008; Zhou et al., 2008).”
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. (2009, background): “Recently, it has been shown that TGF-b can antagonize RORgt function and thus promote regulatory T cell development over Th17 effector cell differentiation (Zhou et al., 2008).”
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells (2011, background): “Also, ROR-t and Foxp3, the respective lineagespecific transcription factors for TH17 and Treg cells, are coexpressed in naive CD4 T cells exposed to TGF-, but Foxp3 is dominant and antagonizes ROR-t function unless IL-6 is present (Zhou et al., 2008).”
CD4+T Cells: Differentiation and Functions (2012, background): “TGF-β alone, at high concentration, can divert lineage differentiation towards iTreg development, through the induction of FOXP3 [63, 64].”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “…transcription factor in Th17 cell lineage (Ivanov et al., 2006), was highly upregulated in Fr. II and III, indicating that RORC-FoxP3 double-positive population, which was recently described in mice (Yang et al., 2008a; Zhou et al., 2008), exists in humans as well in Fr. II and III (Fig- ure S6B).”
Plasticity of CD4+ T cell lineage differentiation. (2009, background): “T cells that coexpress RORgt and Foxp3 have been identified in vivo in both mice and humans (Zhou et al., 2008a; Voo et al., 2009).”
Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, neutral): “…large numbers of two homeostatically regulated and developmentally related populations of CD4 T cells, IL-17+ helper Th17 cells and Foxp3+ regulatory T cells (Treg) (Bettelli et al., st & Microbe 4, 337–349, October 16, 2008 ª2008 Elsevier Inc. 337 2006; Ivanov et al., 2006; Zhou et al., 2008).”
TGF-β Activation and Function in Immunity (2013, background): “Mechanistically, Foxp3 and RORγt can directly interact with each other, and Foxp3 binding to RORγt inhibits RORγt function by preventing its interaction with the IL-17 gene promoter (104, 107, 108).”