Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.

By Zhongjun Zhou, S. Apte, R. Soininen, R. Cao, G. Baaklini, R. Rauser, Jianming Wang, Yihai Cao, K. Tryggvason. Proceedings of the National Academy of Sciences of the United States of America, 2000

844 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/834de3674d44494a418e381ec8260ba5a1a0404e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zena Werb
2. W. Parks
3. Christopher M. Overall
4. C. López‐Otín
5. I. Stamenkovic
6. M. Egeblad
7. H. Ra
8. C. Libert

In Genetics

1. C. López‐Otín
2. M. Goldring
3. Zena Werb
4. M. Egeblad

In Hematology

1. I. Stamenkovic
2. W. Parks
3. H. Ra
4. C. López‐Otín
5. Christopher M. Overall
6. Zena Werb
7. M. Egeblad

Citations in the corpus

• Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation (2006, background): “Recent MMP single gene knock-out studies have evidenced that the affected mice do not show any particular diseases (114,115).”
• Human and mouse proteases: a comparative genomic approach (2003, background): “In fact — with the exception of MT1 – MMP -null mice, which have skeletal abnormalities and die shortly after birt”
• Physiology and pathophysiology of matrix metalloproteases (2010, background): “MMP-14 null mice die within 3 weeks, showing severe developmental abnormalities related to deficiencies in ECM processing, such as dwarfism, skeletal dysplasia and defective vascularization (Holmbeck et al. 1999; Zhou et al. 2000).”
• New functions for the matrix metalloproteinases in cancer progression (2002, background): “, thereby potentially allowing the endothelial cells to invade further into the tumour tissue, and Mmp14 - and Mmp9 -null mice have impaired angiogenesis during developmen”
• Metalloproteinases and Wound Healing (2015, background): “The loss of MT1-MMP leads to defective type I collagen turnover and loss of MMP-2 activation.(49,50) MT1MMP acts to regulate epithelial cell proliferation during wound healing by altering the expression of 230 CALEY, MARTINS, AND O’TOOLE”
• The control of chondrogenesis (2006, background): “The membrane-bound MT1-MMP (MMP-14), which has a broader range of expression than MMP-9, is essential for chondrocyte proliferation and secondary ossification [Zhou et al., 2000].”
• Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development (2003, background): “CTGF regulates the availability of local factors required for growth plate angiogenesis Angiogenesis at the growth plate requires localized proteolytic modification of the ECM to permit invasion by endothelial cells, and MMPs play essential roles in this process (Vu et al., 1998; Zhou et al., 2000).”
• Extracellular matrix remodelling: the role of matrix metalloproteinases (2003, background): “MMP-14 also appears to play a role in angiogenesis as MMP-14-deficient mice display defective angiogenesis during development [109].”