The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation.

By Tiffany M. Phillips, W. McBride, F. Pajonk. Journal of the National Cancer Institute, 2006

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HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion (2008, background): “Indeed, it has recently been reported that CD44+/CD24− mammary stem cells are relatively resistant to radiation and chemotherapy in vitro and in mouse models (Phillips et al., 2006).”
Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “[229] T.”
Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “These CSCs were also found to be responsible for tumor reoccurrence and capable of establishing metastases (Phillips et al. 2006; Li et al. 2008).”
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, background): “Tumorsphere culture has been widely used to assess the self-renewal potential of stem cells and cancer stem cells [5,14,32,39].”
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. (2011, background): “On the other hand, CSCs aswell as normal stem cells possess an enhanced ROS defense system (Diehn et al., 2009; Phillips et al., 2006).”
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “Moreover, IL-6 gene expression showed up in MCF-7–derived spheroids (our present results), which have been shown to contain a high proportion of CD44+CD24– cells (38).”