Epithelial–mesenchymal plasticity in carcinoma metastasis

By J. Tsai, Jing Yang. Genes & Development, 2013

1,150 citations recorded by the source corpus.

A developmental program termed epithelial–mesenchymal transition (EMT) plays a critical role in promoting metastasis in epithelial-derived carcinomas. Recent studies also implicate its reverse program, mesenchymal–epithelial transition (MET), in this metastatic process. In this review, Tsai and Yang discuss the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and the potential for targeting these programs when treating metastatic diseases.

Subfields: Cancer Research, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/035aae384740f077e1045dad374045912e930b66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. David A. Baker
2. Y. Hao
3. P. ten Dijke

In Oncology

1. David M. Gonzalez
2. D. Medici
3. P. ten Dijke

Citations in the corpus

• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “At the same time, epithelial cells adopt the traits of a mesenchymal phenotype, notably motility and susceptibility to invasion and metastasis (Figure 3) [60].”
• Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “Furthermore, EMT process involves a number of cell functions which contribute to the imposition of mesenchymal traits on epithelial cells and thus can play a role in metastasis.(361,362) As EMT is well associated with cancer metastasis, tumor heterogeneity, and consequent drug resistance, the inters”
• The RNA binding protein quaking regulates formation of circRNAs. (2015, neutral): “Since EMT is widely regarded to have an important role in the progression of carcinomas to metastasis (Scheel and Weinberg, 2012; Tsai and Yang, 2013) it will be interesting to examine the influence of QKI-mediated circRNAs in cancers.”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Moreover, many of the mechanisms that are involved in inducing EMT are also capable of maintaining the dormant state of circulating cancer cells (140).”
• The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (2018, background): “Moreover, the strength of metastasis is associated to the epithelial-to-mesenchymal transition (EMT) [214].”