Induction of Pancreatic Differentiation by Signals from Blood Vessels

By E. Lammert, O. Cleaver, D. Melton. Science, 2001

1,092 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/827cb550be1d7c2897303284558bd6aa0b3e99d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Guoqiang Gu
2. Jolanta Dubauskaite
3. D. Melton
4. S. Levenberg
5. C. Iadecola

In Molecular Biology

1. A. Armulik
2. G. Genové
3. S. Levenberg
4. C. Wright
5. F. C. Pan
6. Guoqiang Gu
7. Jolanta Dubauskaite
8. D. Melton

In Surgery

1. C. Wright
2. F. C. Pan
3. Guoqiang Gu
4. Jolanta Dubauskaite
5. D. Melton

Citations in the corpus

• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, methodology): “2A,C) and by staining with Wisteria fluoribunda agglutinin (WFA, which stains ducts but not blood vessels) (Lammert et al., 2001).”
• Engineering vascularized skeletal muscle tissue (2005, background): “Cocultures with endothelial cells may also be important for inducing differentiation of engineered tissues, as embryonic endothelial cells are critical for the earliest stages of organogenesi”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “…in cancer, is proposed by many studies but is still largely unclear (indicated by ‘‘?’’). development, the developing vasculature has been shown to have a role in tissue induction that goes beyond the simple supply of nutrients and oxygen (Lammert et al., 2001; Matsumoto et al., 2001).”
• Generation of functional human pancreatic β cells in vitro (2014, background): “Incorporating pancreatic niche cells, such as mesenchymal or endothelial cells, into cultures of stem-cell-derived pancreatic cells may be beneficial (Sneddon et al., 2012; Lammert et al., 2001).”
• The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors (2002, background): “with those reported here, we propose that Pdx1 expression marks a territory of endoderm with intrinsic foregut competence, with this region becoming further subdivided by specific intercellular signaling events driving cells towards liver or pancreas specificatio”
• Organogenesis of lymphoid tissues (2003, background): “It is of interest that for pancreas and liver organogenesis, the earliest signals were shown to be derived from vasculogenic endothelial cell”
• Pancreas organogenesis: From bud to plexus to gland (2011, background): “[In mouse, some report that two ventral pancreas ‘‘buds’’ are first formed, with one regressing during gut rotation (Lammert et al., 2001), in association with the process of the dorsal to ventral pancreas joining that occurs at E12.”
• Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. (2005, neutral): “For example, it has been shown that normal development of liver or pancreas requires unknown paracrine factor(s) released from endothelial cells (46, 47) and hepatocyte growth factor secreted from liver endothelial cells promotes hepatocyte proliferation (48).”