The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

By Y. Kawaguchi, Bonnie Cooper, M. Gannon, M. Ray, Raymond J MacDonald, C. Wright. Nature Genetics, 2002

1,062 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/08f24f273c88a5c43ff1881f273a9a58f1ffedd0

How researchers see this paper

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In Genetics

1. R. DePinho
2. D. Hanahan

In Molecular Biology

1. R. DePinho
2. N. Bardeesy
3. D. Tuveson
4. Alec C. Kimmelman
5. K. Frese
6. T. Jacks
7. A. Maitra
8. C. Wright

In Surgery

1. D. Hanahan
2. C. Wright
3. F. C. Pan
4. Alec C. Kimmelman

Citations in the corpus

• The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, neutral): “4A) (Krapp et al., 1998; Gradwohl et al., 2000; Kawaguchi et al., 2002).”
• Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. (2007, background): “, 2001) is turned on during the early stages of embryonic pancreatic development by expressing a Cre recombinase under the control of the Pdx1 or P48 promoters (Kawaguchi et al., 2002; Kim and MacDonald, 2002).”
• Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia (2012, background): “Animal Models The LSL-Kras and p48-Cre strains have been described previously (Jackson et al., 2001; Kawaguchi et al., 2002).”
• Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006, methodology): “We crossed Smad4lox homozygous mice to either the Pdx1-Cre or Ptf1a-Cre transgenic mice (Gu et al. 2002; Kawaguchi et al. 2002) (hereafter, for brevity, Cre will be used for references to both strains together); these transgenes direct Cre recombinase expression to the epithelial lineages of the emb”
• Pancreas organogenesis: From bud to plexus to gland (2011, background): “‘‘Global deletion’’ of Pdx1 or Ptf1a in the early foregut epithelium blocks pancreas development and subsequently allows only large cystic ducts to form (Offield et al., 1996; Kawaguchi et al., 2002).”
• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. (2003, background): “, 2001) and P48 mice (Kawaguchi et al., 2002) were previously described.”
• Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. (2003, background): “…an extensive independent study by Tuveson and colleagues of mice harboring LSL-KrasG12D and either a different Pdx1-Cre allele or a p48-Cre allele (Kawaguchi et al. 2002; S.R. Hingorani, E.F. Petricoin, A. Maitra, V. Rajapaske, C. King, M.A. Jacobetz, B.A. Hitt, Y. Kawaguchi, L.A. Liotta, H.C.…”
• Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis (2011, background): “Methods Summary Mouse strains were described previousl”
• Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine (2011, neutral): “For developing organs, whole mount X-gal staining was performed as described previousl”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “…Ptf1-p48 promoters are active in the common progenitors of all pancreatic cell types with relatively restricted expression outside of the pancreas (Pdx1 is also expressed in the developing duodenum and stomach, and Ptf1-p48 is expressed in the cerebellum) (Kawaguchi et al. 2002; Gu et al. 2003).”