Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology.

By F. Kuhajda. Nutrition (Burbank, Los Angeles County, Calif.), 2000

794 citations recorded by the source corpus.

This review documents the changing perspectives on the function of fatty-acid synthase and fatty-acid synthesis in human tumor biology. With the recent discovery that human cancer cells express high levels of fatty-acid synthase and undergo significant endogenous fatty-acid synthesis, our understanding of the role of fatty acids in tumor biology is expanding. Once considered largely an anabolic-energy-storage pathway, fatty-acid synthesis is now associated with clinically aggressive tumor behavior and tumor-cell growth and survival and has become a novel target pathway for chemotherapy development. These findings will ultimately enhance our understanding of fatty acids in tumor biology and may provide new diagnostic and therapeutic moieties for patient care.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8279fbff3d1bfeccce0c4cf762f748beb22aa1f7

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Citations in the corpus

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis (2007, background): “Finally, a third hallmark, functionally related to the glycolytic pathway but commonly forgotten, is an increased de novo fatty acid (FA) synthesi”
Factors affecting odd- and branched-chain fatty acids in milk: A review (2006, background): “Wongtangtintharn et al. (2004) showed that branched-chain fatty acids inhibited fatty acid synthesis in tumour cells, which is recognised as a useful route for developing cancer treatments since cancer cells are more dependent on fatty acid biosynthesis than healthy cells (Kuhajda, 2000).”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “Further, increased activity of lipogenesis enzymes are implicated in tumor growth: fatty acid synthetase (FASN) is overexpressed in cancer cells (Kuhajda 2000), and inhibition of FASN activity has been shown to kill cancer cells and hinder the growth of tumors in xenograft models (Lupu & Menendez…”
Fatty acid synthase and cancer: new application of an old pathway. (2006, background): “More recently, increased expression of fatty acid synthase (FAS) has emerged as a phenotype common to most human carcinomas (2).”