Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms

By L. Friedman, Robert Kolter. Molecular Microbiology, 2003

783 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/81eb4f0cac41476439fb22521f86d6897e0cbfc8

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In Ecology

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Citations in the corpus

• The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens (2019, result): “Others that were annotated as being involved in biofilm formation did not show up in the screen because the strain background used here, strain PA14, uses the exoploysaccharide matrix carbohydrate Pel (47) in contrast to the Psl carbohydrate used by another well characterized strain, strain PAO1 (48”
• Biofilm in Implant Infections: Its Production and Regulation (2005, background): “coli), have been reported to play important roles for biofilm formation (30-35).”
• Pseudomonas aeruginosa Biofilms (2020, background): “Pel is responsible for the pellicle biofilm which is formed at the air-liquid interface of a static broth culture [32].”
• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “The pel locus (referring to pellicle, a biofilm formed at the air-medium interface), containing the genes pelA to -G, is responsible for synthesis of the glucose-rich component of the matrix, whereas the psl locus (polysaccharide synthesis locus), containing the genes pslA to -O, is responsible for ”
• The Social Lives of Microbes (2007, background): “…of S. Crusz. are many components found in the ECM that may be involved in holding the biofilm structure together, including alginate, the lectin LecA, and carbohydrate polymers (Davies & Geesey 1995, Diggle et al. 2006, Friedman & Kolter 2004, Matsukawa & Greenberg 2004, Nivens et al. 2001).”
• Bacterial Extracellular Polysaccharides in Biofilm Formation and Function (2015, background): “For example, the common strain PA14 does not synthesize Psl yet retains the ability to form bio fi lms (74).”
• Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “Two primary EPS components are Pel and Psl (Friedman and Kolter 2004a,b; Jackson et al. 2004; Matsukawa and Greenberg 2004; Vasseur et al. 2005; Ma et al. 2006).”
• Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor (2008, methodology): “Several studies have shown that increased production of Pel or Psl EPS by P. aeruginosa results in a wrinkled colony morphology (Friedman and Kolter, 2004a,b; Hickman et al., 2005; Sakuragi and Kolter, 2007).”