Signal transduction by the JNK group of MAP kinases.

By R. Davis. Cell, 2000

4,516 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/814350258c460a0b62880e9d82dd08b5c71beae8

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In Molecular Biology

1. R. Seger
2. R. Kaufman
3. Simone Fulda
4. Yoav D. Shaul
5. Zhijian J. Chen
6. Shuqun Zhang
7. Walter Kolch
8. C. Hill

In Pharmacology

1. Shuqun Zhang
2. H. Beere
3. M. Thelen
4. D. Townsend
5. K. Tew
6. E. K. Kim
7. E. Choi
8. K. Debatin

Citations in the corpus

• Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling (2001, background): “Here we report that NF-κB complexes downregulate the c-Jun amino-terminal kinase (JNK) cascad”
• Targeting JNK for therapeutic benefit: from junk to gold? (2003, background): “and the demonstration that it is a member of the mitogen-activated protein kinase (MAPK) group of signalling protein”
• Receptor for RACK1 Mediates Activation of JNK by Protein Kinase C (2005, background): “Several MAP3Ks, including members of the MEKK family, ASK1, MLK, TAK1, and TPL-2, have been reported to act as MAP3Ks for JNK (Davis, 2000).”
• Understanding MAPK Signaling Pathways in Apoptosis (2020, background): “ASK1 (apoptosis signal-regulating kinase 1) is a MAP kinase kinase kinase (MAP3K) of JNK and p38 MAPK, which is preferentially activated by ROS (reviewed in [127]).”
• The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. (2008, background): “JNK activation also plays an important role in regulating apoptosis (Chang and Karin, 2001; Davis, 2000; Yu et al., 2004).”
• Molecular motors and mechanisms of directional transport in neurons (2005, background): “JIPs can form oligomeric complexes and simultaneously bind to three components of the JNK signalling pathway, including JNK, and are therefore regarded as scaffolding proteins for JNK pathway kinase”
• Necrosis: a specific form of programmed cell death? (2003, background): “Protein kinase JNK of MAP kinase family (also called stress-activated protein kinase, SAPK) is the major protein kinase involved in stress-induced apoptosis [60], and there are some data indicating that this kinase also participates in necrotic cell death.”
• Nuclear retinoid receptors and the transcription of retinoid-target genes. (2004, neutral): “1) (Morgan, 1997; Davis, 2000; Pearson et al., 2001).”
• Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors (2001, background): “However, p38 phosphorylates activating transcription factor-2, which then drives both the c-jun promoter and the ternary complex factor Elk-1, which activates the c-fos promoter [20].”
• Cellular processing of platinum anticancer drugs (2005, background): “, whereas others have indicated that JNK activation in response to cisplatin signals a protective response and is important for cell surviva”
• TAK1 is a ubiquitin-dependent kinase of MKK and IKK (2001, background): “6 ), which in turn activates the JNK–p38 kinase pathwa”