Molecular motors and mechanisms of directional transport in neurons

By N. Hirokawa, R. Takemura. Nature Reviews Neuroscience, 2005

865 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bbce1fedc074d4f94fa0b16a2d24e1c203632088

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Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. (2006, background): “Multiple plus-end microtubule motors could contribute to mitochondrial transport, but the most likely candidates in axons are members of the kinesin-1 and kinesin-3 subfamilies (Hirokawa and Takemura, 2005).”
Microtubule acetylation promotes kinesin-1 binding and transport. (2006, background): “Long-distance intracellular delivery is driven by kinesin and dynein motor proteins that ferry cargoes along microtubule tracks [1, 2].”
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses (2009, positive): “Mitochondrial transport has been shown to be dependent on kinesin family 1 (KIF5) motor proteins (Tanaka et al., 1998; Hiro- kawa and Takemura, 2005).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The ribosome recycling factor [791] plays an important role in the dissociation of the large and small subunits of a ribosome [792].”
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders (2007, background): “Kinesin KIF17, a plus-end-directed motor , transports NMDAR-containing vesicles together with the adaptor protein LIN10 (also known as MINT1 or XII) along microtubules in dendrites to nascent synapses (for a review, see Ref”
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons (2008, neutral): “Cargo localization depends on motor activity and microtubule organizatio”
The axonal transport of mitochondria (2005, background): “Organelle surface receptors for motor proteins are thought to target the correct motility machinery to the correct organelle type (Guzik and Goldstein, 2004; Hirokawa and Takemura, 2005).”
Axon degeneration mechanisms: commonality amid diversity (2005, background): “Axonal transport is a complex bidirectional process that involves many motor protein”
Kinesin superfamily motor proteins and intracellular transport (2009, background): “2; LAMP2, lysosome-associated membrane protein 2; LIS1, lisencephaly 1; M6PR, mannose-6-phosphate receptor; mRNP, messenger ribonucleoprotein; NF, neurofilament; NR2B, NMDA (N-methyl-d-aspartate)-type glutamate receptor 2B; PAR, partitioning defective; PARP1, poly(ADP-ribose) polymerase 1; PtdIns(3,”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Similarly, cytoplasmic dynein is linked to glycine receptor through the scaffolding protein gephyrin (Caviston and Holzbaur, 2006; Hirokawa and Takemura, 2005; Maas et al., 2006).”
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (2009, background): “However, with our finding that MTs grow into spines, it is possible that cargos are also transported by MT-dependent motors toward synaptic sites (Hirokawa and Takemura, 2005; Kneussel, 2005).”
Animal models of Alzheimer's disease and frontotemporal dementia (2008, background): “Axonal transport along microtubules is mediated by kinesin and dynein protein”
Polarity and intracellular compartmentalization of Drosophila neurons (2007, background): “Current models of traffic into dendrites rely on plus-end directed motors [36,37], but we predict that minus-end directed motors will be important for anterograde traffic in, at least, Drosophila dendritic arborization dendrites.”
The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, background): “The trafficking of these packets is microtubule dependent, and transport is an active process involving motor proteins such as dynein and kinesin (Hirokawa & Takemura 2005).”