Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

By E. Smaele, F. Zazzeroni, S. Papa, D. U. Nguyen, R. Jin, Joy Jones, R. Cong, G. Franzoso. Nature, 2001

610 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/aef13f54c79c15fafc08d806eb231f042d712a9d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Sebastian M. B. Nijman
2. A. Dirac
3. T. Brummelkamp
4. René Bernards
5. Robert F. Schwabe
6. Marcus E. Peter
7. Weimin He
8. J. Kurreck

In Molecular Biology

1. René Bernards
2. Sebastian M. B. Nijman
3. A. Dirac
4. T. Brummelkamp
5. Robert F. Schwabe
6. D. Brenner
7. Marcus E. Peter
8. J. Kurreck

In Oncology

1. René Bernards
2. Sebastian M. B. Nijman
3. Robert F. Schwabe
4. A. Dirac
5. T. Brummelkamp

Citations in the corpus

• To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “…NF-kB and JNK pathways has recently come to light and was implicated to be responsible for the transient activation of JNK in response to TNFa (De Smaele et al., 2001; Javelaud and Besancon, 2001; Tang et al., 2001a; Reuther-Madrid et al., 2002; Papa et al., 2003; reviewed in Franzoso et al.,…”
• T Cell-Intrinsic Requirement for NF-κB Induction in Postdifferentiation IFN-γ Production and Clonal Expansion in a Th1 Response1 (2003, background): “However, in addition to Bcl-3 and Bcl-2 it is possible that still other factors, such as growth arrest and DNA damage protein (GADD) 45 or , are also involved downstream from NF- B (64, 65).”
• Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways (2006, background): “Prolonged TNF-induced JNK activation requires the absence of NF- B activity (9, 37).”
• NF‐κB protects from the lysosomal pathway of cell death (2003, methodology): “However, compared with other protective genes induced by NF-kB, Spi2A is certainly not unique in this regard (De Smaele et al., 2001).”
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB (2003, methodology): “This was immunoprecipated with either non-immune serum (n.i.) or Flag antibody from both untreated cells (basal) or cells treated for 20 min. with TNF-a(20 0 ) and lysates were incubated with GST-IkBa (1-72) in the presence of 32P-gATP (upper panel).”