Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

By P. Gold, George P. Chrousos. Molecular Psychiatry, 2002

1,330 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Physiology

View Paper: https://www.semanticscholar.org/paper/80ff39953420f07da3baa6a9913f7e6830cb6c4e

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Citations in the corpus

The molecular neurobiology of depression (2008, neutral): “By contrast, atypical depression, a subtype characterized by hyperphagia and hypersomnia, seems to be associated with hypocortisolaemi”
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “Chronic stress is a risk factor for major depression in individuals with genetic vulnerability (Holsboer and Barden, 1996; Gold and Chrousos, 2002).”
Exercise and mental health. (2017, background): “HPA dysfunction seen in anxiety or depression can be characterized by heightened or reduced cortisol production, hypersecretion of corticotrophin releasing hormone [95] and compromised sensitivity to glucocorticoids [96].”
The Adaptive Calibration Model of stress responsivity (2010, neutral): “Cortisol levels, for example, are at their zenith within an hour of awakening, decline sharply across the morning hours and then reach their lowest diurnal levels around bedtime. with the amygdala playing a crucial role (Ganzel et al., 2010; Gold and Chrousos, 2002; Herman et al., 2003).”
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression (2013, background): “12 In the past, substantial research has been devoted to the identiﬁcation of subtypes of depression 20 based on clinical correlates, treatment response or observed symptom proﬁles.”
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, positive): “Importantly, melancholic symptoms are associated with HPA hyperactivation and sustained cortisol elevation (Gold & Chrousos, 2002; Taylor & Fink, 2008), which tend to suppress inflammation.”
Sex Differences in Stress-Related Psychiatric Disorders: Neurobiological Perspectives (2014, background): “Evidence suggests that CRF is elevated in brains of patients with depression and PTSD, perhaps as a result of CRF hypersecretion [90; 91; 92].”
Burnout: Moving beyond the status quo. (2017, background): “…subtypes, such as depression with melancholic features and depression with atypical features, have been linked to opposite autonomic (e.g., increased vs. decreased sympathetic activity), endocrine (e.g., hyper- vs. hypocortisolism), and immune profiles (Gold & Chrousos, 2002; Lamers et al., 2013).”
The stress system in the human brain in depression and neurodegeneration. (2005, background): “Gold et al. (1995) and Gold and Chrousos (2002) propose that the classic form of major depression, i.e. ''melancholic depression'', that goes with decreased food intake, insomnia, lack of affective responses to external events, and a general state of pathological hyperarousal, would be due to a…”
Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration (2015, background): “There is accumulating evidence that HPA axis and inflammatory dysregulations differ between subtypes of depression, such as typical and atypical depression, which may suggest differences in pathophysiological processes (e.g., Gold & Chrousos 2002, Halbreich 2005).”
A new view on hypocortisolism. (2005, background): “post-traumatic stress disorder (PTSD), irritable bowel syndrome (IBS), low back pain (LBP), burnout, and atypical depression (Griep et al., 1998; Heim et al., 1998, 2000; Pruessner et al., 1999; Gold and Chrousos, 2002; Gur et al., 2004; Roberts et al., 2004; Rohleder et al., 2004).”
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System (2008, background): “Sustained stressful experience can induce despair and increase the risk of clinical depression and drug abuse (Gold and Chrousos, 2002; Volkow and Li, 2004; Fox et al., 2007; Koob and Kreek, 2007).”
Is burnout a depressive disorder? A reexamination with special focus on atypical depression. (2014, background): “…sensitivity, resulting in significant social or occupational impairment; and hypocortisolism, a biological marker of altered functioning of the hypothalamic-pituitaryadrenocortical (HPA), or “stress,” axis (APA, 1994; Gold & Chrousos, 2002; Tops, Riese, Oldehinkel, Rijsdijk, & Ormel, 2008).”
Depression: a case of neuronal life and death? (2004, background): “Stress Decreases Adult Neurogenesis A key connection between neurogenesis and depression comes from studies of stress, which can precipitate or worsen depression (Brown et al 2003; Gold and Chrousos 2002) and is often used as a model in preclinical studies (Willner 1990).”