Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
By F. Lamers, N. Vogelzangs, Kathleen R. Merikangas, De Jonge, A. Beekman, B. Penninx. Molecular Psychiatry, 2013
699 citations recorded by the source corpus.
Subfields: Food Science, General Agricultural and Biological Sciences
View Paper: https://www.semanticscholar.org/paper/563e0d5169526cf35db11d84ab91c2da01630a22
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In Food Science
In General Agricultural and Biological Sciences
Citations in the corpus
- Burnout: Moving beyond the status quo. (2017, background): “…subtypes, such as depression with melancholic features and depression with atypical features, have been linked to opposite autonomic (e.g., increased vs. decreased sympathetic activity), endocrine (e.g., hyper- vs. hypocortisolism), and immune profiles (Gold & Chrousos, 2002; Lamers et al., 2013).”
- Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, positive): “Inflammation is likely restricted to a subgroup of patients, and appears to be especially common in association with atypical symptoms (e.g., Lamers et al., 2013; Rethorst et al., 2015).”
- Depression and obesity: evidence of shared biological mechanisms (2018, methodology): “Three large cohort studies found higher C-reactive protein (CRP) concentrations in MDD patients with increased neurovegetative features, as compared to other patients and healthy controls [21, 90, 91].”
- Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017, background): “For example, melancholic depression is associated with elevated HPA axis activity (15, 16), whereas individuals with atypical depression appear to have higher levels of proinflammatory markers (16).”
- Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016, background): “others, including tricyclic antidepressants, may exacerbate glycaemic dysfunction or have little effect on glucose homeostasis (46,47).”
- Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “Some studies [123,127] even suggest a relative hypocortisolism in atypical depression.”
- Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential (2015, background): “These results are especially interesting considering that inflammation levels are particularly elevated among depressed individuals with somatic symptoms [28], specifically appetite and weight gain [27].”
- Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta‐analysis (2015, background): “Further, persons with atypical depression have significantly higher levels of inflammatory markers, body mass index, waist circumference and triglycerides, and lower HDL cholesterol than those with melancholic depression (55).”
- Inflammation: depression fans the flames and feasts on the heat. (2015, background): “Differences in inflammatory patterns are likely, giventheheterogeneityof themajordepressionpopulation(173), and thus multiple biomarkers could provide a clearer picture of inflammatory status than a single assay, facilitating identification of the best candidates for anti-inflammatory interventions ”