UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

By M. Bostick, Jong Kyong Kim, P. Esteve, Amander T. Clark, S. Pradhan, Steven E. Jacobsen. Science, 2007

1,406 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/80fd0190c2dd3b0d322ff963e64c40690600db53

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In Molecular Biology

Citations in the corpus

Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “One explanation for this observation came from recent reports of another protein, nuclear protein 95 (NP95, also known as UHRF1 ), that interacts with DNMT1 and PCN”
Conservation and divergence of methylation patterning in plants and animals (2010, methodology): “We also compared methylation of mouse wild-type ES cells with an ES cell line containing a targeted disruption allele ofUhrf1 (5, 27, 34) and found that loss of Uhrf1 caused a reduction of CG methylation (from ∼80% to ∼18%) (Table S2).”
Epigenetic modifications and human disease (2010, background): “The ubiquitin-like plant homeodomain and RING finger domain-containing protein 1 (UHRF1) could perform a similar function, tethering DNMT1 to hemimethylated DNA, thanks to its SET and RING associated–domain, that shows strong preferential binding to hemimethylated CpG”
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “The pattern of DNA methylation is then faithfully maintained during DNA replication by the maintenance methyltransferase Dnmt1, which is recruited to replication foci via its physical interaction with the ubiquitin-like plant homeodomain and RING finger domain 1 (Uhrf1) that strongly binds to hemime”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “Uhrf1 has further been shown to be essential for maintenance DNA methylation during cell division (Bostick et al., 2007; Sharif et al., 2007), a property that is no longer required in postmitotic cells.”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “1 ) and that UHRF1 is required for the association of DNMT1 with chromati”
Ki-67: more than a proliferation marker (2018, background): “The associated proteins include UHRF1, which binds H3K9me3 and DNA methyltransferase DNMT1 (Bostick et al. 2007); SUZ12, a component of H3K27 methyltransferase complex PRC2 (Pasini et al. 2004); and TIP5, the major component of the nucleolar remodeling complex (NoRC) which contributes to the silent ”
Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. (2014, background): “The knockout embryonic stem cells show loss of DNA methylation, enhanced susceptibility to DNA replication arrest, increased sensitivity to DNA damaging agents, impaired maintenance of higher-order chromatin structure, and spurious transcription of repetitive DNA elements (Bostick et al., 2007; Shar”
Epigenetic Determinants of Cancer. (2016, background): “For DNMT1, the protein UHFR1 and proteins associated with it seem to facilitate the targeting of this protein to DNA replication and other sites (Bostick et al. 2007; Nishiyama et al. 2013).”