TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

By L. Runnels, Lixia Yue, D. Clapham. Science, 2001

765 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/8034f8303d8400dfe08547bccad1be242df261f7

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Citations in the corpus

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family (2002, neutral): “and is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activit”
An introduction to TRP channels. (2006, background): “1 agonist (131) I HEK SB-366791 TRPV1 6-900nM antagonist (61, 147) I,Ca,(45)Ca HEK SB-366791 TRPV4 >10μM inactive (147) Ca HEK SB-366791 TRPM8 10μM inactive (122) I HEK SB-452533 TRPV1 10nM antagonist (148) I, Ca HEK SB-452533 TRPM8 571nM antagonist (114, 122) I HEK SKF-96365 TRPC3 5μM antagonist (5”
The transient receptor potential family of ion channels (2011, background): “In TRPM6 and TRPM7 an atypical αkinase domain is involved in regulation of channel function [22,23].”
LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability (2001, methodology): “An analysis of LTRPC7 function has also been performed by Clapham and colleague”
The trp ion channel family (2001, background): “Identified in a yeast two-hybrid screen as a protein interacting with PLC-β 1 , it is the first member of the TRPM group to be expressed as a functional ion channe”
Identification of a cold receptor reveals a general role for TRP channels in thermosensation (2002, background): “Among members of this subfamily, TRPM2 and TRPM7 have been electrophysiologically characterized and shown to behave as bifunctional proteins in which enzymatic activities associated with their long C-terminal domains are believed to regulate channel openin”
TRP channels as cellular sensors (2003, background): “TRPM6 and TRPM7 are unique among ion channels because they also contain functional kinase domain”
The TRP Superfamily of Cation Channels (2005, background): “The protein kinase was identified in one report in a screen for PLC-interacting proteins (153).”
A key role for TRPM7 channels in anoxic neuronal death. (2003, background): “As IOGD currents and (45)Ca(2) uptake were best activated by ROS from the NO pathway, we examined functional C-terminal kinase domain (Runnels et al., 2001; Nadler et al., 2001).”
The functional network of ion channels in T lymphocytes (2009, background): “The cloning of TRPM7 (originally named LTRPC7 or TRPPLIK) and studies on heterologous cell types clarified the molecular identity of the outward-rectifying MIC (MagNuM) current, and raised new issues of the channel-gating mechanism (131, 132).”