Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

By K. Schlingmann, S. Weber, M. Peters, L. N. Nejsum, H. Vitzthum, K. Klingel, M. Kratz, E. Haddad, E. Ristoff, D. Dinour and 6 more. Nature Genetics, 2002

790 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/6e82993219b820c05baafe91b96394bfd805ce45

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In Plant Science

1. D. Clapham
2. C. Montell

Citations in the corpus

• The TRP Superfamily of Cation Channels (2005, background): “The highly related chanzyme, TRPM6, was identified as the mutated gene in patients with hypomagnesemia (164, 165).”
• Renal control of calcium, phosphate, and magnesium homeostasis. (2015, background): “Mutations in TRMP6 result in hypomagnesemia with secondary hypocalcemia (67,68).”
• Magnesium: nutrition and metabolism. (2003, background): “The gene product encodes for a protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity, which might be involved in magnesium absorption (Schlingmann et al., 2002).”
• An introduction to TRP channels. (2006, background): “TRPM6 mutations in human result in hypomagnesemia with secondary hypocalcemia (153, 154), and the high Mg2+ permeability of these channels (147) suggests that TRPM7 may be important for general Mg2+ homeostasis, whereas TRPM6 functions specifically in intestine and kidney (149).”