Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

By Kaveh Ashrafi, F. Chang, J. Watts, Andrew G. Fraser, R. Kamath, J. Ahringer, Gary Ruvkun. Nature, 2003

1,039 citations recorded by the source corpus.

Subfields: Aging, Biochemistry, Physiology

View Paper: https://www.semanticscholar.org/paper/802e0d99876b2c983aab69cb12fc9823abade784

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. J. Ahringer
2. W. Kaelin
3. Ronald H. A. Plasterk
4. F. Simmer
5. R. Kamath
6. Michael O. Hengartner
7. Titus Kaletta
8. Andrew G. Fraser

In Biochemistry

1. W. Kaelin
2. T. Walther
3. Robert V Farese
4. M. Alves‐Bezerra
5. David E Cohen

In Physiology

1. W. Kaelin
2. T. Walther
3. Robert V Farese
4. T. Balla
5. Cori Bargmann
6. M. Alves‐Bezerra
7. David E Cohen

Citations in the corpus

• Chemosensation in C. elegans. (2006, background): “Intestinal fat storage is regulated by insulin, TGF beta, and serotonin signaling, which derive in part from sensory neuroendocrine pathways (Ashrafi et al., 2003; Ogg et al., 1997; Sze et al., 2000; Thomas et al., 1993).”
• Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions (2003, methodology): “elegans using this RNAi library or other techniques (Gönczy et al. 2000; Maeda et al. 2001; Dillin et al. 2002; Piano et al. 2002; Ashrafi et al. 2003; Lee et al. 2003; Pothof et al. 2003).”
• A large-scale RNAi screen in human cells identifies new components of the p53 pathway (2004, neutral): “jpg" NDATA ITEM> ]> RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the identification of components of cellular signalling pathway”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “elegans causes fat accumulation mimicking the effects of inactivation of the insulin receptor homolog (57).”
• Lipid Droplets And Cellular Lipid Metabolism (2012, background): “Screens in Caenorhabditis elegans (44) and Drosophila (45) revealed a plethora of genes involved in fat storage.”
• The plasticity of aging: insights from long-lived mutants. (2005, neutral): “(In worms, fat accumulation can be uncoupled from longevity [Ashrafi et al., 2003; Kenyon et al., 1993; Kimura et al., 1997; Wolkow et al., 2000].)”
• The Concept of Synthetic Lethality in the Context of Anticancer Therapy (2005, methodology): “RNAi is a powerful method for silencing genes in worms and fruitflies, and collections of interfering RNAs have been created to facilitate high-throughput genome-wide screens in these organism”
• The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “elegans , leads to increased fat accumulation, recapitulating the phenotype of inactivation of DAF-2, the insulin-like receptor in worm”