Lipid Droplets And Cellular Lipid Metabolism

By T. Walther, Robert V Farese. Annual Review of Biochemistry, 2012

1,550 citations recorded by the source corpus.

Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage and degradation to viral replication. These processes are functionally linked to many physiological and pathological conditions, including obesity and related metabolic diseases. Despite their important functions and nearly ubiquitous presence in cells, many aspects of LD biology are unknown. In the past few years, the pace of LD investigation has increased, providing new insights. Here, we review the current knowledge of LD cell biology and its translation to physiology.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ecaf5acf303a4754a74854b3478ec6a0d70621ce

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Alves‐Bezerra
2. David E Cohen
3. Carla C. C. R. de Carvalho
4. Maria-José Caramujo

In Molecular Biology

1. M. Alves‐Bezerra
2. David E Cohen
3. Carla C. C. R. de Carvalho
4. Maria-José Caramujo

In Physiology

1. M. Alves‐Bezerra
2. David E Cohen
3. Carla C. C. R. de Carvalho
4. Maria-José Caramujo

Citations in the corpus

• Lipid Droplet Biogenesis (2014, neutral): “com of LD cell biology and physiology are discussed in numerous recent reviews [6–10].”
• Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “Instead, AT may regulate glucose homeostasis indirectly by regulating lipid homeostasis [43].”
• Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.”
• The Various Roles of Fatty Acids (2018, background): “These triacylglycerols and sterol esters are then surrounded by a phospholipid monolayer and specific proteins thus forming lipid droplets, which are ubiquitously present in eukaryotic and prokaryotic cells (see [171,172].”
• Triglyceride metabolism in the liver (2017, positive): “Second to white adipose tissue, the liver has the next greatest capacity to store TG in LDs, such that overnight fasting leads to hepatic LD formation that accommodates FA derived from adipose tissue lipolysis (267).”