Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

By Steven J. Smith, S. Cases, D. Jensen, Hubert C. Chen, E. Sande, B. Tow, D. Sanan, J. Raber, R. Eckel, Robert V Farese. Nature Genetics, 2000

925 citations recorded by the source corpus.

Subfields: Biochemistry, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/7fb7e0384d591d36de4cc693ce54bd9ac1a6d897

How researchers see this paper

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In Biochemistry

1. M. Alves‐Bezerra
2. David E Cohen
3. Gerald I. Shulman
4. V. Samuel
5. Douglas P Lee
6. R. Coleman
7. Manabu T. Nakamura
8. R. Medzhitov

In Physiology

1. V. Samuel
2. B. Cannon
3. J. Nedergaard
4. Gerald I. Shulman
5. M. Alves‐Bezerra
6. David E Cohen
7. B. Spiegelman
8. Haiming Cao

In Surgery

1. Gerald I. Shulman
2. V. Samuel
3. M. Alves‐Bezerra
4. Douglas P Lee
5. David E Cohen
6. R. Coleman
7. R. Medzhitov
8. M. Kotas

Citations in the corpus

• Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (2012, positive): “In actuality, DGAT1 knockout mice have reductions in both tissue triglyceride and diacylglycerol content (Smith et al., 2000) and are resistant to diet-induced obesity and insulin resistance.”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “3 DGAT1 Acyl CoA: diacylglycerol Oacyltransferase 1 Lean and resistant to diet-induced obesity (351)”
• Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. (2002, background): “A gene encoding a protein with acylCoA:diacylglycerol acyltransferase (DGAT1 - EC 2.3.1.20) activity was recently identified (Cases et al. 1998) and shown to completely inhibit lactation when knocked out in the mouse (Smith et al. 2000).”
• Regulation of energy metabolism by long-chain fatty acids. (2014, background): “DGAT2 KO mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138 5.3.”
• Enzymes of triacylglycerol synthesis and their regulation. (2004, background): “The production of TAG in milk depends on hormone-induced up-regulation of the enzymes of TAG synthesis, but no studies have investigated the now-cloned enzymes, except for DGAT-1 whose absence completely blocks milk production [161].”
• Triglyceride metabolism in the liver (2017, positive): “High fat-fed Dgat1 knockout mice are also resistant to obesity and have improved insulin responsiveness (238).”
• Nonshivering thermogenesis and its adequate measurement in metabolic studies (2011, background): “Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.”