c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

By C. Grandori, N. Gomez-Roman, Zoë A. Felton-Edkins, C. Ngouenet, D. Galloway, R. Eisenman, Robert J White. Nature Cell Biology, 2005

684 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7fa1af9f0115fb266dcb693cc4ed005605540e72

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Citations in the corpus

The interplay between MYC and HIF in cancer (2008, background): “MYC also directly activates RNA polymerases I- and III-dependent ribosomal RNA genes that are necessary for ribosomal assembl”
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. (2007, background): “…DNA binding, and associating with the Pol III component TFIIIB to increase tRNA and 5S rRNA levels (Arabi et al., 2005; Gomez-Roman et al., 2003; Grandori et al., 2005). eIF4F complex components eIF4E and eIF4G, as well as eIF2α (described below), are also c-Myc transcriptional targets (Coller…”
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis (2005, background): “MYC, which encodes a transcription factor, c-Myc (herein termed Myc), plays a central role in the regulation of cell size, cell proliferation, and apoptosis (6, 11, 28, 40, 41) through its regulation of RNA polymerase I-, II-, and III-dependent genes (2, 17, 18, 39).”
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells (2012, positive): “Because Myc is a direct activator of the genes transcribed by RNA polymerases I and III (Felton-Edkins et al., 2003; Grandori et al., 2005), as well as by RNA polymerase II, increased rRNA was expected to account for most Mycelevated RNA; this was confirmed by using a BioAnalyzer (Agilent).”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “2003) and RNA polymerase I (Arabi et al. 2005; Grandori et al. 2005; Grewal et al. 2005).”
MYC on the Path to Cancer (2012, background): “In this regard, Myc also regulates RNA Pol I- and Pol III-mediated transcription in addition to its role in regulating RNA Pol II genes (Felton-Edkins et al., 2003; Gomez-Roman et al., 2003; Grandori et al., 2005; Kenneth et al., 2007).”
Myc's broad reach. (2008, background): “However Myc has a nucleolar function in that it directly stimulates RNA polymerase I transcription of rDNA (Arabi et al. 2005; Grandori et al. 2005).”
Transcriptional Amplification in Tumor Cells with Elevated c-Myc (2012, neutral): “It was also evident that rRNA and tRNA genes became occupied by c-Myc (Figure 2A), as reported previously (Arabi et al., 2005; Gomez-Roman et al., 2003; Grandori et al., 2005).”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “Both MYC and NMYC directly bind and transcriptionally activate a cohort of genes encompassing both rRNA genes, RP genes, and other translational regulators (Boon et al., 2001; Coller et al., 2000; Grandori et al., 2005).”
MYC, Metabolism, and Cancer. (2015, background): “MYC is a unique transcription factor that stimulates transcription driven by all three RNA polymerases (I, II, and III) to produce components of the ribosome: rRNA, ribosomal proteins, and small 5S rRNAs (153, 154).”
The multifunctional nucleolus (2007, background): “For example, the c-Myc protein seems to drive cell growth and tumorigenesi”
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (2008, background): “For example, the growth-promoting function of MYC is, at least partially, exerted in the nucleolus at sites of ribosomal DNA transcription, and the FBW7γ isoform controls the growth-promoting activity of MYC in the nucleolu”
THE HISTONE DEACETYLASE SIRT6 IS A NOVEL TUMOR SUPPRESSOR THAT CONTROLS CANCER METABOLISM (2012, neutral): “…the transcription factor MYC has recently been described as a global regulator of ribosome biogenesis (Arabi et al., 2005; Dai and Lu, 2008; Grandori et al., 2005; Grewal et al., 2005), leading us to speculate that SIRT6 and MYC could cooperate in the regulation of ribosomal gene…”
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “In addition, c-Myc also impacts profoundly on cell growth by activating genes Oncogene encoding ribosomal proteins and translation factors (Adhikary and Eilers, 2005), and by stimulating transcription of ribosomal RNA genes by Pol I (Arabi et al., 2005; Grandori et al., 2005).”
MYC, metabolism, cell growth, and tumorigenesis. (2013, background): “Knockdown of miR-92 levels in serum-stimulat- Glutamine Mitochondrial biogenesis Ribosome biogenesis Lactate Glucose Mct1 ATP ROS PRDX ATP ATP ATP Pol MYC NTPs, dNTPs NH3, CO2, H + I, II, III Max Figure 5.”