Mechanisms linking obesity to insulin resistance and type 2 diabetes

By S. Kahn, R. Hull, K. Utzschneider. Nature, 2006

5,325 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/7f77138b4d0d097c5c2e483d578b92c6cc7aa239

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Citations in the corpus

The role of the gut microbiota in energy metabolism and metabolic disease. (2009, background): “the reduction of physical activity in our daily lives [4].”
Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, background): “The metabolic syndrome should be considered as a clinical diagnosis that is mechanistically driven by a complex combination of factors including impaired fat accumulation, insulin action, and immunity [18].”
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Such ectopic WAT areas are mostly located within the visceral cavity, and include intrahepatic (discussed in the section on Ectopic Abbreviations: ALT, Alanine transaminase; M2, Alternatively activated macrophages; AMPK, AMP-activated protein kinase; ARG1, arginase-1; AST, aspartate transaminase; β-”
Evaluating the glucose tolerance test in mice. (2008, background): “TYPE 2 DIABETES IS CHARACTERIZED BY GLUCOSE INTOLERANCE, which is contributed to by peripheral (muscle, fat, and liver) insulin resistance as well as islet -cell dysfunction (17).”
Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “Obesity is currently one of the most serious public health challenges worldwide, especially in the Western world, because of its increasing prevalence and its contribution to a complex of symptoms collectively called the “metabolic syndrome” [1,2].”
Global Burden of Cancer (2006, background): “This lifestyle results in positive energy imbalance that further leads to insulin resistance (or metabolic syndrome) characterized by hyperinsulinemia, dyslipidemia, hypertension, and glucose intolerance [18].”
Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes (2012, neutral): “This notion that type 2 diabetes is irreversible is supported by the strong association with genetics and family history, the high prevalence of microvascular complications, and the loss of beta cell mass and function frequently already present at diagnosis.(2,3) Despite these observations, 16% of U”
Light at night increases body mass by shifting the time of food intake (2010, background): “Increased body mass and reduced glucose tolerance are indicative of a prediabetic-like state (15).”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “Insulin resistance is a major metabolic abnormality in the great majority of patients with type 2 diabetes, and the incidence of this disease has reached epidemic proportions around the globe (Hupfeld et al., 2010; Kahn et al., 2006).”