Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.

By Jingsong Xu, Fei Wang, Alexandra Van Keymeulen, P. Herzmark, A. Straight, K. Kelly, Y. Takuwa, N. Sugimoto, T. Mitchison, H. Bourne. Cell, 2003

727 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ede3f43f2f2f942f6640e1ef57a7770a7337a861

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In Cell Biology

1. M. Schwartz
2. A. Horwitz
3. J. Parsons
4. Masanori Nakayama
5. M. Amano
6. Kozo Kaibuchi
7. Valerie M. Weaver

In Immunology and Allergy

1. M. Schwartz
2. A. Horwitz
3. J. Parsons
4. N. Borregaard
5. C. Gerard
6. Valerie M. Weaver

In Molecular Biology

1. A. Horwitz
2. J. Parsons
3. M. Schwartz
4. Masanori Nakayama
5. Y. Bae
6. M. Amano
7. C. Serhan
8. S. Rhee

Citations in the corpus

• Neutrophils, from marrow to microbes. (2010, background): “The tail end of polarized neutrophils contains a contractile actomyosin system controlled by Ga12 and Ga13 type G protein coupled receptors, CDC42, Rho A, Rho-dependent kinase, ROCK, and myosin II (Xu et al., 2003; Van Keymeulen et al., 2006).”
• Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “Conversely, actomyosin bundles and stable adhesions are crucial for generating the cell rea”
• Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity (2010, result): “Similar results have been shown for HL-60 cells stimulated with fMLP - the number of cells with flattened morphologies and multiple pseudopods is increased by the inhibition of Rho, Rho-kinase or myosin II [Xu et al., 2003].”
• Controlling cell behavior electrically: current views and future potential. (2005, unknown): “EGFR ND ND Yes (7) Yes (219) VEGFR ND ND Yes (4) Yes (218) FGFR Yes (206) Yes (57) Yes (104) Yes (217) G proteins Yes (76, 212) ND Yes (37, 48, 169) No (221) PKC Yes (69) Yes (58) Yes (199) Yes (150), no (164) PLC Yes (76, 140) Yes (58) Yes (111, 211) ND PI-3K Yes (111) ND Yes (40, 169) Yes (218) IP”
• Mechanism of B-Cell Receptor-Induced Phosphorylation and Activation of Phospholipase C-γ2 (2004, background): “Alternatively, because intracellular concentration of PIP3 is the net result of phosphorylation by PI 3-kinase and dephosphorylation by PTEN and because PIP3 is not evenly distributed throughout the plasma membranes (14, 15, 18, 51), Akt and Btk might be activated by different pools of PIP3, and the”
• International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “The “backness” or uropod of a migrating cell is characterized by concentrations of molecules such as PTEN, RhoA, and the G12/13 family of G proteins (Funamoto et al., 2002; Xu et al., 2003).”
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, unknown): “Polarization of neutrophils, which is important for efficient transendothelial migration, is mediated by the organization of filamentous actin (F-actin) cytoskeleton at the leading edge (375, 461).”
• Non-muscle myosin II takes centre stage in cell adhesion and migration (2009, unknown): “The signals leading to specification of the cell rear and protrusion are spatially segregate”