Rapid secretion of interleukin-1β by microvesicle shedding

By A. MacKenzie, H. Wilson, E. Kiss-Toth, S. Dower, R. North, A. Surprenant. 2001

822 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/7e3e36babbddc2c5230f6c0d712b9013aedd4206

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Théry
2. G. Raposo
3. S. Fink
4. Marina Colombo
5. G. López‐Castejón
6. D. Brough
7. L. Zitvogel
8. B. Cookson

In Molecular Biology

1. G. Raposo
2. C. Théry
3. Marina Colombo
4. S. Fink
5. Rienk Nieuwland
6. D. Brough
7. G. López‐Castejón
8. B. Cookson

In Physiology

1. Marina Colombo
2. G. López‐Castejón
3. D. Brough
4. G. Palmer
5. P. Pelegrín
6. C. Théry
7. C. Gabay
8. A. Surprenant

Citations in the corpus

• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Microvesicles or exosomes are a major pathway for fast secretion of interleukin 1 , which lacks a signal peptide (MacKenzie et al., 2001; Wilson et al., 2004; Bianco et al., 2005).”
• Membrane microparticles: two sides of the coin. (2005, background): “For instance, the presence of interleukin-1 (IL-1) was observed in shed MPs ( 33 ), and MPs are a source of aminophospholipid substrates of secretory phospholipase A2 for the generation of lysophosphatidic acid, a potent proinflammatory mediator and platelet agonist (17).”
• Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor (2006, methodology): “…only known physiological stimuli for this rapid processing and release of bioactive IL-1b are allogenic cytotoxic T cells and activation of the ATP-gated P2X7 receptor (P2X7R) (Perregaux and Gabel, 1994; Perregaux et al, 1996; Mackenzie et al, 2001; Kahlenberg and Dubyak 2004; Ferrari et al, 2006).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, methodology): “Larger vesicles, by contrast, can be visualized by fluorescence microscopy, and shedding from cells of vesicles of 0.5 µm to a few micrometers in diameter has been observed by video microscopy (Di Vizio et al. 2012, MacKenzie et al. 2001, Muralidharan-Chari et al. 2009).”
• Caspase‐1‐dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages (2006, background): “Unlike other cytokines, IL-1β and IL-18 lack secretion signals and several mechanisms have been proposed to account for their release (Rubartelli et al., 1990; Hamon et al., 1997; Andrei et al., 1999; 2004; MacKenzie et al., 2001; Wewers, 2004; Marty et al., 2005).”