Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

By P. Pelegrín, A. Surprenant. EMBO Journal, 2006

1,479 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/95cf9250c97d9a7edb497cb5baa40f0ed73e7345

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. G. Núñez
2. L. Franchi

In Molecular Biology

1. G. Núñez
2. Kate Schroder
3. L. Franchi
4. Yuan He
5. J. Tschopp
6. Raúl Muñoz-Planillo
7. M. Xia
8. Yang Zhang

In Physiology

1. G. Núñez
2. Kate Schroder
3. J. Tschopp
4. L. Franchi
5. C. A. Dinarello

Citations in the corpus

• Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, background): “For example, excessive levels of ATP were described as one of the first endogenous DAMPs to induce NLRP3 inflammasome formation and activation, a mechanism involving high concentrations of extracellular ATP binding to the purinergic P2X7 receptor (104).”
• The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis (2009, background): “Evidence indicates that extracellular ATP also results in the opening of a pore mediated by pannexin-1 (refs”
• The Family of Connexin Genes (2009, background): “While pannexins can form channels connecting the cytoplasm and extracellular space analogous to connexin hemichannels [11,12, 13 ], it is not clear that they form intercellular channels except in certain overexpression systems [11,14,15] (see Chapter 12).”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Pelegrin P, Surprenant A. Pannexin-1 medi- ates large pore formation and interleukin1beta release by the ATP-gated P2X7 receptor.”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “Caspases-4/5/11 induce pyroptosis through the processing of GSDMD, and pannexin-1, which is a protein channel that releases ATP from the cell [17,71,128].”
• NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? (2010, background): “Although the mechanism by which cytoplasmic K + concentration modulates NLRP3 inflammasome activation is unknown, it seems that intracellular K + depletion alone is not sufficient for NLRP3-mediated IL-1β processing and secretio”