Disruption of CREB function in brain leads to neurodegeneration
By T. Mantamadiotis, T. Lemberger, S. Bleckmann, H. Kern, O. Kretz, Ana Villalba, F. Tronche, C. Kellendonk, Daniel Gau, J. Kapfhammer and 3 more. Nature Genetics, 2002
713 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7e3e16883f98e4268a6a9747f68532476cc6f31c
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In Cellular and Molecular Neuroscience
In Molecular Biology
- Christoph Handschin
- B. Spiegelman
- Jiandie D. Lin
- Wenli Yang
- Marc Uldry
- J. St-Pierre
- Joel T. Dudley
- R. Hen
Citations in the corpus
- Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, background): “This observation, along with the emerging role in osteoblasts of other transcription factors such as, among others, Schnurri-3 or FOXO that are not osteoblast specific (Jones et al., 2006; Manolagas and Almeida, 2007 ), suggest that besides cell-specific transcription factors, other ones, more broa”
- Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain (2004, background): “This feet-clasping phenotype is observed in several mutants with neurological impairment due to neurodegeneration (Mangiarini et al., 1996; Mantamadiotis et al., 2002; Wang et al., 2002).”
- Regulation of transcription factors by neuronal activity (2002, neutral): “cgi?Q=camk2*[sym]&ORG=Mm">CaMKII )-expressing forebrain cells causes neurodegeneration in the striatum and hippocampu”
- Identification of type 2 diabetes subgroups through topological analysis of patient similarity (2015, background): “Pathways enriched in subtype 3 include a-adrenergic signaling, which is implicated in diverse physiological functions, in particular those of the cardiovascular and central nervous systems (41, 42); synaptic long-term depression (43); CREB (cAMP response element– binding protein) signaling in neuron”
- Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “*Contact: bruce_spiegelman@dfci.harvard.edu DOI 10.1016/j.cell.2006.09.024”
- Excitotoxicity and stroke: identifying novel targets for neuroprotection. (2014, positive): “transcription are required for NMDAR-dependent and other neurotrophic factor-dependent neuronal survival during development and in adulthood (Hansen et al., 2004; Lonze et al., 2002; Mantamadiotis et al., 2002; Monti et al., 2002) and can render neurons resistant to excitotoxicity and other apoptoti”