Beyond oxidative stress: an immunologist’s guide to reactive oxygen species

By C. Nathan, A. Cunningham-Bussel. Nature reviews. Immunology, 2013

1,431 citations recorded by the source corpus.

Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.

Subfields: Immunology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/7e1be2e10d1ef33a430298b5f5618455bb19ce52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

In Nutrition and Dietetics

Citations in the corpus

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “While various cell types can produce ROS by different machineries to regulate and influence cellular processes (Trachootham et al., 2008; Bae et al., 2011; Ray et al., 2012; Nathan and Cunningham-Bussel, 2013; Navarro-Yepes et al., 2014; Reczek and Chandel, 2014; Schieber and Chandel, 2014; Gorlach ”
Direct regulation of the NADPH oxidase RBOHD by the PRR-associated kinase BIK1 during plant immunity. (2014, background): “The generated extracellular ROS have been proposed to act as antimicrobials, cross-linkers of the plant cell wall to block pathogen ingress, or to act as local and systemic secondary messengers to trigger additional immune responses, such as gene expression or stomatal closure (Doke, 1983; Lamb and ”
Alternative Antimicrobial Approach: Nano-Antimicrobial Materials (2015, background): “ROS, considered the most effective determinant for both the in vitro and in vivo cytotoxicity of NM, are induced indirectly due to respiratory chain disruption or directly by the NM themselves [16].”
Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications (2021, background): “However, these actions require a high level of ions which in turn generate additional damage to the transmembrane system [41].”
Oxidative stress: a concept in redox biology and medicine (2015, background): “Constructive criticism in this sense has been voiced repeatedly [11,12,17].”
The role of oxidative stress during inflammatory processes (2013, background): “…involving redox reactions triggering cellular oxidative stress play critical roles in the pathophysiology of inflammation (Liaudet et al., 2009; Nathan and Cunningham-Bussel, 2013), a concept that had been already proposed almost 30 years ago in a milestone review article on the biochemistry…”
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress☆ (2017, background): “high levels of H2O2 occur in oxidative distress, exemplified by cellkilling in the respiratory burst of neutrophils [119] or in toxicity”
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? (2016, background): “Major prooxidant-antioxidant reactions are summarized in Figure 1 [17, 21, 26, 38].”