A New Class of Genetic Element, Staphylococcus Cassette Chromosome mec, Encodes Methicillin Resistance in Staphylococcus aureus

By Y. Katayama, Teruyo Ito, K. Hiramatsu. Antimicrobial Agents and Chemotherapy, 2000

1,125 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7d53cd79d848eb3bd33150f3a7e3680e3fd3e97f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Infectious Diseases

In Molecular Biology

Citations in the corpus

Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus (2002, methodology): “The primary criteria originally used for the classification of the mec element into three structural types were the structure of the mecA complex (mecA gene with the upstream regulatory region) and the nature of the ccrAB allele (12), the function of which is associated with the precise insertion an”
Novel Type V Staphylococcal Cassette Chromosome mec Driven by a Novel Cassette Chromosome Recombinase, ccrC (2004, methodology): “Recombinant plasmids were introduced into S. aureus cells by electroporation, as described previously ( 22 ).”
Novel Type of Staphylococcal Cassette Chromosome mec Identified in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains (2002, methodology): “PBP 2 is encoded by the mecA gene, which is carried by a large mobile genetic element that is designated staphylococcal cassette chromosome mec (SCCmec) and that is integrated on the chromosomes of MRSA strains isolated from hospitals in various countries throughout the world (11, 12, 14, 15).”
Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus (2001, methodology): “SCCmec was defined as the DNA element on the MRSA chromosome demarcated by a pair of direct repeats and inverted repeats, having ccr genes required for its movement and carrying the mecA gene (14, 17).”
Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “Methicillin resistance is mediated by the gene mecA that is spread via horizontal gene transfer of the mobile genetic element named staphylococcal cassette chromosome mec (SCC mec ) (Katayama et al , 2000).”
Pathogenicity Islands in Bacterial Pathogenesis (2004, background): “Although mecA could be could be transferred experimentally by phage transduction to other staphylococcal species, no naturally occurring transducing bacteriophage which is capable of transferring genetic material across the species barrier has been described (177).”
Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant Staphylococcus epidermidis Strain (2005, background): “Previous structural analysis of identified SSCmec elements suggests that the ccrAB genes may form an independent mobile SSC element that mediates staphylococcal interspecies transfer of antimicrobial or virulence genes (25, 26).”
Genomic islands: tools of bacterial horizontal gene transfer and evolution (2008, background): “This antibiotic resistance is facilitated mostly by genes located on a GEI-designated staphylococcal cassette chromosome mec (SCCmec) (Katayama et al., 2000).”
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology (2018, background): “and acquired resistance via the incorporation of a mecA gene into the chromosome at a specific site (25, 26).”
Classification of Staphylococcal Cassette Chromosome mec (SCCmec): Guidelines for Reporting Novel SCCmec Elements (2009, neutral): “identified and designated as SCCmec (8, 11).”
Antimicrobial resistance: the example of Staphylococcus aureus. (2003, background): “(32) demonstrated that mecA is part of a genomic island designated staphylococcal cassette chromosome mec (SCCmec).”