The many faces of macrophage activation

By D. Mosser. Journal of Leukocyte Biology, 2003

2,049 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/7d306f102ba91817cf5d4fe35e9b8744e6bfa754

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. F. Martínez
5. P. Allavena
6. P. Murray
7. S. Badylak
8. Carol A. Colton

In Neurology

1. A. Mantovani
2. S. Badylak
3. Carol A. Colton
4. P. Murray
5. S. Gordon
6. T. Koh
7. A. Chawla
8. Jianping Ye

Citations in the corpus

• Monocyte and macrophage heterogeneity (2005, background): “A series of in vitro experiments has led to macrophages often being ascribed activation state”
• Circular RNA and its mechanisms in disease: From the bench to the clinic. (2018, background): “Macrophages are activated through two different routes: classical activation (M1) and alternative activation (M2) (Mosser, 2003).”
• Epidemiology of and Diagnostic Strategies for Toxoplasmosis (2012, background): “Thus, there is a need for downregulating effectors, a role devoted at least partially to IL-10 and transforming growth factor (TGF- ), which modulate macrophage activation (233).”
• Exploring the full spectrum of macrophage activation (2008, background): “Regulatory macrophages can also arise during the later stages of adaptive immune responses, the primary role of which seems to be to dampen the immune response and limit inflammatio”
• Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “The ‘classically activated’ or M1 phenotype emerges as a result of macrophage interaction with pro-inflammatory signals such as Interferon-g (IFN-g) and microbial products such as lipopolysaccharide (LPS) [17].”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “Interestingly, immune complexes in concert with microbial molecules or inflammatory cytokines have been shown to elicit an M2 form of macrophage activation [14] and TAM are a prototypic M2 population [2, 10, 13].”
• Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas (2008, background): “Certain studies have discovered heterogeneous activation pathways of macrophages that influence various disease processes [1,2].”
• Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. (2009, background): “M2 activated macrophages express IL-12, IL-23, and IL-10high; have high levels of scavenger, mannose, and galactose receptors; produce arginase in the place of arginine, subsequently producing ornithine and polyamines; are involved in polarized Th2 reactions; and possess the ability to facilitate ti”
• Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “First, M1 phenotype is stimulated by microbial products or pro-inflammatory cytokines [IFN-γ, TNF, or Toll-like receptor (TLR) ligands], and the typical characteristics of M1 macrophages include high antigen presentation, high production of IL-12 and IL-23, and high production of nitric oxide (NO) a”